Results 81 to 90 of about 2,099,864 (251)

La langue francaise dans les disciplines non linguistiques: facteur de réussite ou de d’inhibition ? [PDF]

Studii si Cercetari Filologice: Seria Limbi Straine Aplicate, 2018
The French language, the first living language in a school system in great difficulty, has gone from the status of a "second language" to a "foreign language"; it is for this reason that it is laborious to determine the real status of this language in ...
Moulay Mohamed Tarnaoui
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Numerical simulations of sand‐screen performance in unconsolidated prepacked gravel screen

Energy Science & Engineering
This work addresses the ongoing challenge of optimizing sand control screens, attributed to a limited understanding of screen blocking. A novel one‐way computational fluid dynamics and discrete element method (CFD–DEM) coupling technique is presented to ...
Chengyun Ma, Yihua Dou, Jingen Deng, Cheng Hui, Kai Zhao, Yongcun Feng, Liangbin Dou   +6 more
doaj   +1 more source

The Dynamic Character of Northern Hemisphere Flow Regimes in a Near-Term Climate Change Projection

Atmosphere, 2018
The dynamic character of an enstrophy-based diagnostic, previously used in the study of atmospheric blocking, is examined here, in near-term future simulations from the Institut Pierre Simon Laplace Climate Model version 4 (IPSL-CM4) and version 5 (IPSL ...
Andrew D. Jensen, Mirseid G. Akperov, Igor I. Mokhov, Anthony R. Lupo, Fengpeng Sun   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Improving Petrophysical Interpretation of Conventional Log ‎by Determination of Real Bed Boundaries [PDF]

Journal of Sciences, Islamic Republic of Iran, 2017
Proper determination of bed boundaries in layered reservoirs is vital ‎for accurate petrophysical interpretation of conventional logs. In the ‎wellbore, logs continuously measure physical properties of reservoir ‎while the properties change stepwise ...
F. Khoshbakht, M. R. Rasaie, A. Shekarifard   +2 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Experimental Research and Development of Nonlinearity Models for FR1 Range Mixers for Electromagnetic Compatibility Analysis

Доклады Белорусского государственного университета информатики и радиоэлектроники
By using the technology of double-frequency testing, an experimental analysis of nonlinear properties of low-power radio-frequency mixers is performed at frequencies of the n7 band allocated in Belarus for 4G mobile communication systems and the n78 band
E. V. Sinkevich, V. I. Mordachev, Wan Fayu, D. A. Tsyanenka, I. V. Shakinka   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source