Results 51 to 60 of about 1,033,682 (248)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

open access: yesFEBS Letters, EarlyView.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh   +2 more
wiley   +1 more source

Comparative study of blocking and suppression in predictive control

open access: yesRevista Técnica de la Facultad de Ingeniería, 2011
  The performance of predictive controllers based on convolution models can be modified in a number of ways to alleviate the problems of “ringing” and excessive controllers actions.
J. Bastidas, G. Febres, C. Vinante
doaj  

Neuromuscular block [PDF]

open access: yesBritish Journal of Pharmacology, 2006
Descriptions of the South American arrow poisons known as curares were reported by explorers in the 16th century, and their site of action in producing neuromuscular block was determined by Claude Bernard in the mid‐19th century. Tubocurarine, the most important curare alkaloid, played a large part in experiments to determine the role of acetylcholine ...
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

REVIEW ARTICLE/EDUCATIONAL PANEL
How to plan an experiment I. Randomization: current fad or (ever)lasting fashion?

open access: yesArchives of Medical Science, 2006
All those who like experimentation are sooner or later faced with a need of random selection of elements or objects of interest that they want to study (persons, patients, animals, cells, etc.).
Cezary Watała
doaj  

Wolbachia strains wMel and wAlbB differentially affect Aedes aegypti traits related to fecundity

open access: yesMicrobiology Spectrum
Two Wolbachia strains, wMel and wAlbB, have been transinfected into Aedes aegypti mosquitoes for population replacement with the aim of reducing dengue transmission.
Rafael Maciel-de-Freitas   +8 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Geometrical Aspects of the Optics of Linear Fresnel Concentrators: A Review

open access: yesEnergies
Linear Fresnel concentrators (LFR) are widely seen by the scientific community as one of the most promising systems for the production of solar energy via thermal plants or concentrated photovoltaics. The produced energy depends on the optical efficiency
Roberto Grena
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

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