Results 101 to 110 of about 465,440 (342)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A powerful framework for an integrative study with heterogeneous omics data: from univariate statistics to multi-block analysis [PDF]
, 2020 Harold Duruflé +5 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Statistical cryptanalysis of block ciphers
, 2005 Since the development of cryptology in the industrial and academic worlds in the seventies, public knowledge and expertise have grown in a tremendous way, notably because of the increasing, nowadays almost ubiquitous, presence of electronic communication means in our lives.
openaire +1 more source
On Statistical Testing of Block Ciphers
Mathematics and Mathematical Modeling, 2018 Block ciphers form one of the main classes of cryptographic algorithms. One of the challenges in development of block ciphers, like any other cryptographic algorithms, is the analysis of their cryptographic security. In the course of such analysis, statistical testing of block ciphers is often used.
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Bootstrap quantification of estimation uncertainties in network degree distributions
Scientific Reports, 2017 We propose a new method of nonparametric bootstrap to quantify estimation uncertainties in functions of network degree distribution in large ultra sparse networks. Both network degree distribution and network order are assumed to be unknown. The key idea
Yulia R. Gel +2 more
doaj +1 more source
, 2010 In recent years, a variety of extensions and refinements have been developed for data augmentation based model fitting routines. These developments aim to extend the application, improve the speed and/or simplify the implementation of data augmentation ...
Meng, Xiao-Li, van Dyk, David A.
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
A general theory of minimum aberration and its applications
, 2005 Minimum aberration is an increasingly popular criterion for comparing and assessing fractional factorial designs, and few would question its importance and usefulness nowadays.
Cheng, Ching-Shui, Tang, Boxin
core +1 more source