Results 101 to 110 of about 2,308,466 (295)

Characteristics of participants with DNA of tick-borne pathogens detected in blood.

, 2016
Characteristics of participants with DNA of tick-borne pathogens detected in blood.
Joke van der Giessen (357307), Agnetha Hofhuis (413122), Setareh Jahfari (693859), Wilfrid van Pelt (185301), Manoj Fonville (357305), Hein Sprong (20005)   +5 more
core   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

An investigation into the possibility of transmission of tick-borne pathogens via blood transfusion [PDF]

, 1999
STUDY DESIGN AND METHODS: Donors and recipients were asked to complete questionnaires regarding symptoms and risk factors for infection and to provide blood samples for laboratory analysis.
Tengelsen, A., Treadwell, T. A., Marston, E., Chamberland, M., Childs, J. E., Tengelsen, L., Rotz, L. D., Illness Task Force, Transfusion-Associated Tick-Borne, Task Force, Transfusion-Associated Tick-Borne Illness, Schwartz, A., Olson, J. G., Slater, K., Arguin, P. M., Singleton, J.   +13 more
core  

Inside‐Outside ROS Therapeutic Strategy Based on Piezoelectric Nano‐Urchin for Drug‐Resistant Bacteria Biofilm Infections

Advanced Science, EarlyView.
The contribution of this study lies not only in enabling effective treatment of drug‐resistant biofilm infections, but also in establishing a transferable therapeutic paradigm: Ultrasound‐triggered mechanical forces synergistically enhance piezoelectric polarization and nanozyme activity, driving functional ROS generation inside and outside biofilms ...
Xinjian Guo, Jin Yang, Mengjie An, Bingjie Lin, Tao Liu, Limin Zhang   +5 more
wiley   +1 more source

DNA of Ehrlichia muris, hyperendemicity of Babesia microti in Ixodes ricinus and age-related detection of nuclear mitochondrial DNA (NUMTs) in Dermacentor reticulatus from an urban, marshy biotope of South-central Europe

Ticks and Tick-Borne Diseases
The present study was initiated to analyze ticks collected periodically from the vegetation in an urban marshy biotope of central Europe. During the one-year-long study period, 1960 ticks were found, including Ixodes ricinus (n = 1037), Dermacentor ...
Sándor Hornok, Nóra Takács, Paulina Lesiczka, Tim Warbroek, Tijs J.M. van den Bosch, Gergő Keve, Jenő Kontschán, Orsolya Péteri   +7 more
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

A bite so sweet: the glycobiology interface of tick-host-pathogen interactions

Parasites & Vectors, 2018
Vector-borne diseases constitute 17% of all infectious diseases in the world; among the blood-feeding arthropods, ticks transmit the highest number of pathogens. Understanding the interactions between the tick vector, the mammalian host and the pathogens
Pavlina Vechtova, Jarmila Sterbova, Jan Sterba, Marie Vancova, Ryan O. M. Rego, Martin Selinger, Martin Strnad, Maryna Golovchenko, Nataliia Rudenko, Libor Grubhoffer   +9 more
doaj   +1 more source

The Cross-Sectional Study of attitudes towards risk factors of viral infections transmitted by blood-borne pathogens. [PDF]

Rev Esc Enferm USP, 2023
Ivanović S, Trgovčević S, Jovanović MC, Kocić B, Milutinović S.   +4 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source