Results 91 to 100 of about 52,843 (255)

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Molecular epidemiological study on tick-borne pathogens in Qinghai Province, Northwestern China

Biosafety and Health
Recently, there has been a continuous stream of reports on emerging tick-borne pathogens affecting humans. Qinghai Province, located in the northweastern region, is one of China’s major pastoral areas, providing a suitable environment for ticks' survival
Chunfeng Luo, Yonghong Song, Luoyuan Xia, Minxuan Liu, Hao Feng, Licheng Xiao, Ming Xu, Xiangyin Cai, Jianye Cui, Rong Xiang, Jihu Yang, Wei Kan, Yanli Shen, Yuanlian Ma, Zhanhao Zeng, Baohan Liu, Yulian Tao, Huimin Yu, Yi Sun, Xiaorun Wang, Jiafu Jiang   +20 more
doaj   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Hard tick infestation of birds of prey (Aves: Accipitriformes, Strigiformes, Falconiformes) in the Western Palearctic: New data and literature review

Ticks and Tick-Borne Diseases
Tick infestation of songbirds has been extensively studied at global and regional scales but relevant data on birds of prey remain scarce and fragmentary.
Andor Pitó, Attila D. Sándor, Márton Horváth, Szilvia Pásztory-Kovács, Boyan Milchev, Sándor Koleszár, Előd Győrig, Calin Gherman, Benedek Juhász, Lili Sztrehárszki, Attila Mórocz, Gergő Keve, Paulina Lesiczka, Tim Warbroek, Tijs J.M. van den Bosch, Nóra Takács, Jenő Kontschán, Sándor Hornok   +17 more
doaj   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Comprehensive study of ticks and tick-borne diseases in dogs in Nepal: molecular identification, risk analysis and hematological alterations

BMC Veterinary Research
Background Ticks are responsible for the transmission of various viral, bacterial, and protozoal pathogens through their mouthparts while feeding on the blood of the host.
Somnath Aryal, Rebanta Kumar Bhattarai, Kamana Thapa   +2 more
doaj   +1 more source

Characterization of the Blood Bacterial Microbiota in Lowland Tapirs (Tapirus terrestris), a Vulnerable Species in Brazil

Microorganisms
Microbiome studies targeting hypervariable regions of the 16S rRNA gene are suitable for understanding interactions between animals and their associated bacteria.
Anna Claudia Baumel Mongruel, Emília Patrícia Medici, Rosangela Zacarias Machado, Keith Clay, Marcos Rogério André   +4 more
doaj   +1 more source

Blood-Borne Pathogens in Emergency Medicine [PDF]

Annals of Emergency Medicine, 2017
openaire   +2 more sources

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source