Results 41 to 50 of about 117,110 (303)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Transfusion-transmitted infections [PDF]

, 2007
Although the risk of transfusion-transmitted infections today is lower than ever, the supply of safe blood products remains subject to contamination with known and yet to be identified human pathogens.
Florian Bihl, Damiano Castelli, Francesco Marincola, Roger Y Dodd, Christian Brander, M Pittman, MG McEntegart, EL Snyder, G Andreu, JC Faber, JC Faber, SJ Wagner, CD Hillyer, CDC, ME Brecher, MA Blajchman, CT Fang, MT Niu, CF Hogman, M Goldman, CP McDonald, CK Lee, SJ Wagner, D de Korte, M Chassaigne, ME Brecher, ME Brecher, CP McDonald, GA Ortolano, SL Stramer, CG Schuttler, JP Allain, S Kleinman, RY Dodd, MP Busch, S Laperche, J Coste, GM Busch, R Offergeld, C Niederhauser, C Velati, K Soldan, J Pillonel, M Alvarez do Barrio, E Delwart, H Yugi, E Brojer, B Weber, A Yoshikawa, K Soldan, R Biswas, A Sanchez-Quijano, I Cacciola, PF Coleman, B Weber, E Tabor, CJ Liu, D Prati, JM Jongerius, S Levicnik-Stezinar, LH Gould, LN Pealer, CDC, MP Busch, SL Stramer, LR Petersen, B Custer, CT Korves, MH Koppelman, A Manns, EL Murphy, EL Murphy, DF Roucoux, FA Proietti, SL Stramer, EC Vamvakas, MA Blajchman, MR Visconti, MA Blajchman, DM Knowles, W Hladik, SC Dollard, N Regamey, RY Dodd, MA Blajchman, CG Wu, UF Koenigbauer, A Plentz, J Blumel, MH Koppelman, P Gowland, AH Diwan, E Boxall, K Matsubayashi, T Nishizawa, Y Tanaka, WE Hitzler, S Zhong, MJ Jeon, J Akiba, D Kumar, AD Kitchen, G Kinde, M Frey-Wettstein, E Purdy, F Alkassab, HW Reesink, M Mungai, CR Seed, American Association of Blood Banks, A Kitchen, PL Chiodini, O Silvie, DA Leiby, DA Leiby, GA Schmunis, LJ Cardo, A Saito-Ito, DA Leiby, N Hunter, CA Llewelyn, AH Peden, PE Hewitt, AC Ghani, JA Aznar, P Hellstern, JP Pelletier, A Pineda, S Murphy, F Knutson, WC Van Voorhis, J McCullough, RJ Benjamin, B Zavizion, B Zavizion, T Mather, A Ohagen, F Corbin 3rd, RP Goodrich, RP Goodrich, LD Fast, LJ Cardo, PH Ruane, CP Engelfriet, J Debeir   +144 more
core   +1 more source

Season and host-community composition inside roosts may affect host-specificity of bat flies

Scientific Reports
Bat flies are one of the most abundant ectoparasites of bats, showing remarkable morphological adaptations to the parasitic habit, while the relationship with their hosts is characterized by a high level of specificity.
Attila D. Sándor, Alexandra Corduneanu, Sándor Hornok, Andrei D. Mihalca, Áron Péter   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts. [PDF]

, 2017
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of ...
Baumgarth, Nicole, Tracy, Karen E
core   +1 more source

East-to-west dispersal of bird-associated ixodid ticks in the northern Palaearctic: Review of already reported tick species according to longitudinal migratory avian hosts and first evidence on the genetic connectedness of Ixodes apronophorus between Siberia and Europe

Current Research in Parasitology and Vector-Borne Diseases
Birds are long-known as important disseminators of ixodid ticks, in which context mostly their latitudinal, south-to-north migration is considered. However, several bird species that occur in the eastern part of the northern Palaearctic are known to ...
Andor Pitó, Denis Fedorov, Vojtěch Brlík, Jenő Kontschán, Gergő Keve, Attila D. Sándor, Nóra Takács, Sándor Hornok   +7 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Clinical perspectives of emerging pathogens in bleeding disorders. [PDF]

, 2006
As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe ...
Bozzette, Samuel, Diamond, Michael, Koerper, Marion A, Kulkarni, Roshni, Ludlam, Christopher A, Powderly, William G, Ritchie, Bruce, Siegel, Jamie, Simmonds, Peter, Stanley, Samuel, Tapper, Michael L, von Depka, Mario   +11 more
core   +1 more source

Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria [PDF]

, 2016
There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast-relapsing strains in tropical areas, and slow-relapsing strains in temperate areas with seasonal ...
Ghani, A, Karl, S, Mueller, I, Shirreff, G, White, MT   +4 more
core   +4 more sources

Hyalomma rufipes of Asian origin transported to Europe by a migrant bird

Ticks and Tick-Borne Diseases
Hyalomma rufipes is one of the most epidemiologically important ticks in Africa and the Middle East. It is regularly transported by migratory birds and there are chances that these ticks may become sources for the emergence of resident populations in the
Attila D. Sándor, Áron Péter, Joanna B. Wong, Reto Burri, Sándor Hornok   +4 more
doaj   +1 more source