Results 61 to 70 of about 117,110 (303)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Integrated molecular, phenotypic and epidemiological surveillance of antimicrobial resistance in Neisseria gonorrhoeae in Germany

International Journal of Medical Microbiology
Numbers of infections with Neisseria gonorrhoeae are among the top three sexually transmitted infections (STI) worldwide. In addition, the emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae pose an important public-health ...
Kathleen Klaper, Hana Tlapák, Regina Selb, Klaus Jansen, Dagmar Heuer   +4 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Developing a next level integrated genomic surveillance: Advances in the molecular epidemiology of HIV in Germany

International Journal of Medical Microbiology
Advances in the molecular epidemiological studies of the Human Immunodeficiency Virus (HIV) at the Robert Koch Institute (RKI) by laboratory and bioinformatic automation should allow the processing of larger numbers of samples and more comprehensive and ...
Kirsten Hanke, Vera Rykalina, Uwe Koppe, Barbara Gunsenheimer-Bartmeyer, Dagmar Heuer, Karolin Meixenberger   +5 more
doaj   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Active and resolved HCV infections among people with new HIV-1 diagnoses in Germany, 2009–2019

BMC Infectious Diseases
Background HIV and HCV share similar routes of infection. Individuals carrying both viruses experience a faster progression of the liver disease. We have analyzed people with new HIV-1 diagnoses in Germany for active or resolved HCV infection for over ...
Daniel Ivanusic, Amare Eshetu, Hussein Al-Shehabi, Andrea Hauser, Patrycja Klink, Daniel Schmidt, Uwe Koppe, Barbara Gunsenheimer-Bartmeyer, Viviane Bremer, Norbert Bannert   +9 more
doaj   +1 more source

Molecular investigation of endoparasites of marine mammals (Cetacea: Mysticeti, Odontoceti) in the Western Mediterranean

Frontiers in Veterinary Science
IntroductionWhales, dolphins, and porpoises are susceptible to infections by protozoan and metazoan parasites.MethodsIn this study, tissue samples, as well as flatworms and roundworms, were collected from a common bottlenose dolphin (Tursiops truncatus),
Nicolas R. Specht, Gergő Keve, Gergő Keve, Carolina Fernández-Maldonado, Alejandra Cerezo Caro, Nóra Takács, Nóra Takács, Jenő Kontschán, Jenő Kontschán, Sándor Hornok, Sándor Hornok   +10 more
doaj   +1 more source

Health care workers' exposure to blood-borne pathogens in Lebanon [PDF]

Occupational Medicine, 2008
Accidental exposure to blood-borne pathogens (BBPs) is a risk for health care workers (HCWs).To study the pattern of occupational exposure to blood and body fluids (BBFs) at a tertiary care hospital.This study reports a 17-year experience (1985-2001) of ongoing surveillance of HCW exposure to BBFs at a 420-bed academic tertiary care hospital.A total of
Umayya M, Musharrafieh, Abdul Rahman N, Bizri, Nabil T, Nassar, Amal C, Rahi, Ali M, Shoukair, Rita M, Doudakian, Ghassan N, Hamadeh   +6 more
openaire   +2 more sources

A Surface‐engineered Microfluidic Device for Antibody‐Mediated Negative Selection of High‐Quality Sperm for Assisted Reproduction

Advanced Functional Materials, EarlyView.
This study reports a microfluidic device with a functionalized surface utilizing a polyoxazoline coating and covalently immobilized gold nanoparticles and anti‐phosphatidylserine antibody. The device efficiently eliminates pre‐apoptotic and apoptotic spermatozoa and yields sperm with substantially improved quality and low DNA damage, offering a simple ...
Soraya Rasi Ghaemi, David J. Sharkey, Nicole O. McPherson, Markos Negash Alemie, Krasimir Vasilev, Sarah A. Robertson   +5 more
wiley   +1 more source

Ixodid ticks of Western Palearctic bats: ecology, host-parasite relationships, geographic distribution and zoonotic importance

Frontiers in Veterinary Science
Bats in the Western Palearctic are host for diverse array of ectoparasites, including three ixodid ticks (Ixodes ariadnae, I. simplex, and I. vespertilionis), which are highly specialized to parasitize these mammals.
Attila D. Sándor, Attila D. Sándor, Attila D. Sándor, Cristian Domșa, Áron Péter, Sándor Hornok, Sándor Hornok   +6 more
doaj   +1 more source