Results 121 to 130 of about 4,500,736 (296)

Advancements in strategies for overcoming the blood–brain barrier to deliver brain-targeted drugs

Frontiers in Aging Neuroscience
The blood–brain barrier is known to consist of a variety of cells and complex inter-cellular junctions that protect the vulnerable brain from neurotoxic compounds; however, it also complicates the pharmacological treatment of central nervous system ...
Zhichuang Qu, Zhichuang Qu, Juan Luo, Juan Luo, Zheng Li, Zheng Li, Rong Yang, Rong Yang, Jiaxi Zhao, Jiaxi Zhao, Xin Chen, Sixun Yu, Sixun Yu, Haifeng Shu, Haifeng Shu   +14 more
doaj   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Breaking the fortress: a mechanistic review of meningitis-causing bacteria breaching tactics in blood brain barrier

Cell Communication and Signaling
The blood-brain barrier is a physiological protective barrier around blood vessels in the brain. It prevents most bacteria and harmful substances from entering the brain through the blood.
Yingying Quan, Yuxin Wang, Shuji Gao, Shuo Yuan, Shenao Song, Baobao Liu, Yang Wang   +6 more
doaj   +1 more source

Neuropathology of the blood-brain barrier and pharmaco-resistance in human epilepsy

, 2012
Blood–brain barrier dysfunction is implicated in various neurological conditions. Modulating the blood–brain barrier may have therapeutic value. Progress is hindered by our limited understanding of the pathophysiology of the blood–brain barrier in humans,
Martinian, L., Liu, J.Y.W., Figarella-Branger, D., Catarino, C.B., Koepp, M., Sisodiya, S.M., Bartolomei, F., Thom, M.   +7 more
core   +1 more source

Multiwavelength Implantable Oximeter for Wireless Monitoring of Tissue Oxygenation in the Presence of Blood Volume Changes

Advanced Healthcare Materials, EarlyView.
This study presents an implantable, wireless, battery‐free oximeter that can continuously monitor physiologically consistent regional tissue oxygenation under dynamic changes of blood volume. This is achieved through multiwavelength photoplethysmography and validated both via Monte Carlo simulations and in vivo rat studies. Different stress events were
Anat Usatinsky, Hugo L. Higueros‐Garcia, Sadi Loai, Samantha Unger, Jacob Trueb, Yonatan Usatinsky, Rawad Alkallas‐Valdiviezo, Noor Abu Jarad, Jonathan Wu, Hai‐Ling M. Cheng, John A. Rogers, Abraham Vázquez‐Guardado, Daniel Franklin   +12 more
wiley   +1 more source

Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model.

PLoS Biology
To cause meningitis, bacteria move from the bloodstream to the brain, crossing the endothelial cells of the blood-brain barrier. Most studies on how bacteria cross the blood-brain barrier have been performed in vitro using cultured endothelial cells, due
Sumedha Ravishankar, Samantha M Tuohey, Nicole O Ramos, Satoshi Uchiyama, Megan I Hayes, Kalisa Kang, Victor Nizet, Cressida A Madigan   +7 more
doaj   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Unveiling the hidden connection: the blood-brain barrier’s role in epilepsy

Frontiers in Neurology
Epilepsy is characterized by abnormal synchronous electrical activity of neurons in the brain. The blood-brain barrier, which is mainly composed of endothelial cells, pericytes, astrocytes and other cell types and is formed by connections between a ...
Jinkun Han, Ying Wang, Penghu Wei, Di Lu, Yongzhi Shan   +4 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Breaking boundaries: role of the brain barriers in metastatic process

Fluids and Barriers of the CNS
Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3–10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with ...
Nasim Izadi, Peter Solár, Klaudia Hašanová, Alemeh Zamani, Maryam Shahidian Akbar, Klára Mrázová, Martin Bartošík, Tomáš Kazda, Roman Hrstka, Marek Joukal   +9 more
doaj   +1 more source