Results 121 to 130 of about 792,108 (354)

Blood-brain barrier dysfunction and recovery after ischemic stroke

Progress in neurobiology, 2017
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes and cells at the blood-brain interface and maintaining the homeostatic microenvironment of the CNS.
Xiaoyan Jiang, A. Andjelkovic, Ling Zhu, Tuo Yang, M. Bennett, Jun Chen, R. Keep, Yejie Shi   +7 more
semanticscholar   +1 more source

Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms

CNS Neuroscience & Therapeutics, 2020
The blood–brain barrier (BBB) is an important physiological barrier that separates the central nervous system (CNS) from the peripheral circulation, which contains inflammatory mediators and immune cells. The BBB regulates cellular and molecular exchange
Xiaowen Huang, Basharat Hussain, Junlei Chang   +2 more
semanticscholar   +1 more source

Interaction of major facilitator superfamily domain containing 2A with the blood–brain barrier

Neural Regeneration Research
The functional and structural integrity of the blood–brain barrier is crucial in maintaining homeostasis in the brain microenvironment; however, the molecular mechanisms underlying the formation and function of the blood–brain barrier remain poorly ...
Yilun Ma, Taiwei Dong, Fei Luan, Juanjuan Yang, Feng Miao, Peifeng Wei   +5 more
doaj   +1 more source

Permeability of the Blood-Brain Barrier and Transport of Nanobodies Across the Blood-Brain Barrier

Folia Veterinaria, 2018
The presence of a blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier presents animmense challenge for effective delivery of therapeutics to the central nervous system. Many potential drugs, which are effective at their site of action, have
Širochmanová I., Čomor Ľ., Káňová E., Jiménez-Munguía I., Tkáčová Z., Bhide M.   +5 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Brain-Penetrating Peptide Shuttles Across the Blood-Brain Barrier and Extracellular-like Space

, 2019
Here, we describe a combinatorial approach to identify peptide shuttles that successfully traverse the multiple barriers to systemic drug delivery to the brain--1. the blood-brain barrier (BBB) and the 2.
Yen-Liang, Liu, Yuan-I, Chen, Alex, Nguyen, Debadyuti, Ghosh, Jae You, Kim, Xiujuan, Peng, Hsin-Chih, Yeh, Phyllis, Ang, Jasmim, Leal, Xinquan, Liu   +9 more
core   +1 more source

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma

Communications Materials
The blood-brain barrier, essential for protecting the central nervous system, also restricts drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover ...
Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda   +5 more
doaj   +1 more source

Beyond wrecking a wall: revisiting the concept of blood–brain barrier breakdown in ischemic stroke

Neural Regeneration Research
The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral circulation. It tightly modulates the ion transport and nutrient influx, while restricting the entry of harmful factors, and ...
Julia Castillo-González, Elena González-Rey   +1 more
doaj   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis [PDF]

, 2012
Background Type 2 diabetes is a risk factor for Alzheimer's disease (AD), most likely linked to an impairment of insulin signalling in the brain. Therefore, drugs that enhance insulin signalling may have therapeutic potential for AD. Liraglutide (Victoza)
Hunter, Kerry, Holscher, Christian, Hunter Kerry, Hölscher Christian, Kerry Hunter, Christian Holscher   +5 more
core   +1 more source