Results 231 to 240 of about 14,920,139 (352)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Inflammation and oxidative stress are associated with major adverse cardiovascular events in adults with preclinical hypertension. [PDF]

Sci Rep
Gimblet CJ, Kozlova D, Wendt LH, Akbari S, Sun M, Eyck PT, Crowley S, Jalal DI.   +7 more
europepmc   +1 more source

Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease [PDF]

, 2019
Tom G. Richardson, Eleanor Sanderson, Tom Palmer, Mika Ala‐Korpela, Brian A. Ference, George Davey Smith, Michael V. Holmes   +6 more
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Distribution and Genetic Characterization of the MNS Blood Group in Multi-Ethnic Populations of East China. [PDF]

J Blood Med
Xu Z, Fang Z, Lu R, Jiang J, Xie S, Wang M, Jin Y, Liu Z.   +7 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Endogenous Levels, Detection Time, and Symptoms of Gamma-Hydroxybutyric Acid: Results From a Placebo-Controlled Clinical Trial. [PDF]

Basic Clin Pharmacol Toxicol
Faldborg KB, Sørensen LK, Hasselstrøm JB, Andersen CU.   +3 more
europepmc   +1 more source

Blood.

British Journal of Sports Medicine, 1989
E. Cartwright, Helen Ashenbrucker, H. D.T.   +2 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Association of hemodynamic variability during endovascular stroke treatment with functional outcome and parenchymal hemorrhage. [PDF]

Ther Adv Neurol Disord
Chen M, Sauer LD, Potreck A, Kieser M, Bendszus M, Ringleb P, Möhlenbruch M, Schönenberger S.   +7 more
europepmc   +1 more source