Results 51 to 60 of about 5,082,152 (344)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Construction of blood quality monitoring indicator system in blood banks of Shandong

Zhongguo shuxue zazhi
Objective To establish a blood quality monitoring indicator system, in order to continuously improve blood quality and standardized management. Methods Based on the research of literature and standards, and guided by the key control points of blood ...
Qun LIU, Xuemei LI, Yuqing WU, Zhiquan RONG, Zhongsi YANG, Zhe SONG, Shuhong ZHAO, Lin ZHU, Shuli SUN, Wei ZHANG, Jinyu HAN, Xiaojuan FAN, Hui YE, Mingming QIAO, Hua SHEN, Dunzhu GONGJUE, Yunlong ZHUANG   +16 more
doaj   +1 more source

Results Of Testing For HbsAg On Nepalese Blood Donors By Counter-Immuno-Electrophoresis

Journal of Nepal Medical Association, 2003
NA
Basu Dev Sharma, Kathleen Booth, P B Booth, K Kenrick   +3 more
doaj   +1 more source

Blood Utilisation Practices and Quality Indicators at a Tertiary Care Hospital in South Delhi-A Retrospective Study [PDF]

National Journal of Laboratory Medicine, 2020
Introduction: Blood transfusion services have an essential role in the resuscitation and management of patients undergoing elective surgeries and are an integral part of the healthcare system all over the world.
Monal Trisal, Safia Rana, Shaan Khetrapal, Sujata Jetley, Rubeena Naz Mohroo, Zeeba Jairajpuri   +5 more
doaj   +1 more source

An Android based blood bank information retrieval system

Journal of Blood Medicine, 2019
Background: Blood Bank record keeping has been carried out manually over the past decades using paper file management system which is slow for information retrieval and processing and also prone to errors in an emergency situation. Materials and methods:
A. Kayode, A. Adeniyi, R. Ogundokun, Simon Agaba Ochigbo   +3 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Percentages of CD4+CD8+ Double-positive T Lymphocytes in the Peripheral Blood of Adults from a Blood Bank in Bogotá, Colombia

Turkish journal of haematology : official journal of Turkish Society of Haematology, 2019
Objective: CD4+CD8+ double-positive T-cells (DPTs) have been classified as a separate T-cell subpopulation, with two main phenotypes: CD4high CD8low and CD4low CD8high. In recent years, the relevance of DPTs in the pathogenesis of infections, tumors, and
M. S. Gonzalez-Mancera, N. Bolaños, M. Salamanca, Guillermo Orjuela, Ayda N Rodríguez, John M. González   +5 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Trend in seroprevalence of Hepatitis B virus infection among blood donors of coastal Karnataka, India

Journal of Infection in Developing Countries, 2009
Background: Hepatitis B is one of the transfusion transmissible infections. The prevalence of this infection varies across the different geographies. Noting the trend in seroprevalence is useful to assist the preventive strategies.
Karandeep Singh, Sudha Bhat, Shamee Shastry   +2 more
doaj   +1 more source