Results 121 to 130 of about 47,790 (302)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Effects of SARS-CoV-2 vaccination on blood donation and blood banks in India. [PDF]

Ann Med Surg (Lond), 2022
Hunain R, Uday U, Rackimuthu S, Nawaz FA, Narain K, Essar MY, Rehman MU, Ahmad S, Butt A.   +8 more
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Quality monitoring indicator system in blood banks of Shandong: applied in blood donation services, component preparation and blood supply process

Zhongguo shuxue zazhi
Objective To establish an effective quality indicator monitoring system, scientifically and objectively evaluate the quality management level of blood banks, and achieve continuous improvement of quality management in blood bank.
Yuqing WU, Hong ZHOU, Zhijie ZHANG, Zhiquan RONG, Xuemei LI, Zhe SONG, Shuhong ZHAO, Zhongsi YANG, Qun LIU, Lin ZHU, Xiaojuan FAN, Shuli SUN, Wei ZHANG, Jinyu HAN, Haiyan HUANG, Guangcai LIU, Ping CHEN, Xianwu AN, Hui ZHANG, Junxia REN, Xuejing LI, Chenxi YANG, Bo ZHOU, Hui YE, Mingming QIAO, Hua SHEN, Dunzhu GONGJUE, Yunlong ZHUANG   +27 more
doaj   +1 more source

Banking on Blood [PDF]

EBioMedicine, 2016
openaire   +3 more sources

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Performance of Chimeric Trypanosoma cruzi Antigens in Serological Screening for Chagas Disease in Blood Banks. [PDF]

Front Med (Lausanne), 2022
Dos Santos EF, Silva ÂAO, Freitas NEM, Leony LM, Daltro RT, Santos CAST, de Almeida MDCC, de Araújo FLV, Celedon PAF, Krieger MA, Zanchin NIT, Dos Reis MG, Santos FLN.   +12 more
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Application of quality control indicator system in blood banks of Shandong

Zhongguo shuxue zazhi
Objective To establish an effective quality monitoring indicator system for blood quality control in blood banks, in order to analyze the quality control indicators for blood collection and supply, and evaluate blood quality control process, thus ...
Qun LIU, Yuqing WU, Xuemei LI, Zhongsi YANG, Zhe SONG, Zhiquan RONG, Shuhong ZHAO, Lin ZHU, Xiaojuan FAN, Shuli SUN, Wei ZHANG, Jinyu HAN, Xuejing LI, Bo ZHOU, Chenxi YANG, Haiyan HUANG, Guangcai LIU, Kai CHEN, Xianwu AN, Hui ZHANG, Junxia REN, Hui YE, Mingming QIAO, Hua SHEN, Dunzhu GONGJUE, Yunlong ZHUANG   +25 more
doaj   +1 more source