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Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures
Stem Cell Research & Therapy, 2018 Background Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be
S. Oja +4 more
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Drosophila blood cell chemotaxis
Current Opinion in Cell Biology, 2014 Drosophila melanogaster contains a population of blood cells called hemocytes that represent the functional equivalent of vertebrate macrophages. These cells undergo directed migrations to disperse during development and reach sites of tissue damage or altered self.
Evans, I.R., Wood, W.
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Cellular Microbiology, 2003 Drosophila blood cells or haemocytes belong to three lineages: plasmatocytes, crystal cells and lamellocytes. There is no equivalent of a lymphoid lineage in insects which have no adaptive immunity. Haematopoiesis is under the control of a number of transcription factors and signalling pathways (such as GATA factors, JAK/STAT or Notch pathways) most of
Marie, Meister, Marie, Lagueux
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Limited utility of qPCR-based detection of tumor-specific circulating mRNAs in whole blood from clear cell renal cell carcinoma patients [PDF]
, 2020 BACKGROUND: RNA sequencing data is providing abundant information about the levels of dysregulation of genes in various tumors. These data, as well as data based on older microarray technologies have enabled the identification of many genes which are ...
Busch, Jonas +6 more
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Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. [PDF]
, 2018 OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical ...
Barcellos, Lisa F +13 more
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Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein
Nature Communications, 2023 SARS-CoV-2 infection can cause coagulopathic events. Kuhn et al. show by cryo-ET how the Spike protein impacts platelet morphology by binding to the platelet surface, leading to micro-activation; and investigate integrin as possible point of contact.
Christopher Cyrus Kuhn +10 more
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Известия ТИНРО, 2021 State of blood cells is examined for juveniles of pink and chum salmon sampled from Lesnoy Pugachevsky, Taranaisky and Okhotsky hatcheries in Sakhalin in May-June of 2018 and 2019 and caught in the Ochepukha, Pugachevka and Taranay Rivers during their ...
O. V. Zelennikov +2 more
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Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study [PDF]
, 2000 The West of Scotland Coronary Prevention Study (WOSCOPS) showed that pravastatin reduced the risk of coronary heart disease (CHD) events in 6,595 middle-aged hypercholesterolaemic men aged 45-64 years without prior myocardial infarction followed for an ...
Ann Rumley +8 more
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Consensus on Complement Inhibitor Therapy and Management of Paroxysmal Nocturnal Hemoglobinuria
罕见病研究Paroxysmal nocturnal hemoglobinuria (PNH), a rare clonal disease of hematopoietic stem cells caused by mutations in the phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA) gene, may lead to the deficiency of glycosylated ...
Red Blood Cell Disease (Anemia) Group, Chinese Society of Hematology, Chinese Medical Association
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Acta Scientiarum: Animal Sciences, 2018 In this experiment a total of 300 d-old broilers (Ross 308) were randomized across 20 floor pens and reared up to 42 d. Treatments includes: 1) A normal-protein diet (NPD) was formulated according to the Ross 308 recommendation (2014) by corn and soybean
Ali Asghar Saki +3 more
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