How do I analyze the role of red blood cell transfusions on clinical outcome in anemic patients? Disentangling the effect of red blood cell transfusions from pre-operative anemia on post-operative outcome. [PDF]
Loobeek D+3 more
europepmc +1 more source
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock+8 more
wiley +1 more source
Sudden Cardiac Death due to Ventricular Fibrillation in a Dog Following Packed Red Blood Cell Transfusion. [PDF]
Ryave J, Gunasekaran T, Sanders RA.
europepmc +1 more source
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos+17 more
wiley +1 more source
Adhesive Force Between Biconcave Red Blood Cell Membrane and Bulk Substrate. [PDF]
Mu W.
europepmc +1 more source
Objective This study analyzed longitudinal trajectories of soluble Flt1 (sFlt1) levels, placenta growth factor (PlGF) levels, and sFlt1:PlGF ratios in a cohort of pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14–18, 24–26, 30–32, 34–36, and 38–40 weeks), stored at −80°C, and evaluated for serum levels ...
Nilson R. de Jesús+7 more
wiley +1 more source
Prevalence and overlap of white blood cell counts, procalcitonin and C-reactive protein in neonates with invasive bacterial infections. [PDF]
Yin Z+5 more
europepmc +1 more source
Metabolic Consequences of Rheumatoid Arthritis
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry+2 more
wiley +1 more source
Platelet-to-White Blood Cell Ratio and Prognostic Biomarker for Spontaneous Reperfusion After Primary Percutaneous Coronary Intervention. [PDF]
Daungsupawong H, Wiwanitkit V.
europepmc +1 more source
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicine‐specific adverse events.
Lisa K. Stamp+8 more
wiley +1 more source