Results 131 to 140 of about 17,492,293 (382)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

FATAL ANEMIA OF UNKNOWN CAUSE IN A CHILD OF FIVE YEARS, WITH UNUSUAL CELLS IN THE BLOOD [PDF]

, 1909
By WILLISTON W. BARKER
openalex   +1 more source

TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy

Epigenetics
Methylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylase enzyme TET1 can affect the expressions of key oncogenes or tumour suppressor genes, thus contributing to ...
Ji Ren, Xiuying Chen, Jing Li, Yuxin Zan, Shan Wang, Yujie Tan, Yan Ding   +6 more
doaj   +1 more source

Calcium in Red Blood Cells—A Perilous Balance

International Journal of Molecular Sciences, 2013
Ca2+ is a universal signalling molecule involved in regulating cell cycle and fate, metabolism and structural integrity, motility and volume. Like other cells, red blood cells (RBCs) rely on Ca2+ dependent signalling during differentiation from precursor
A. Bogdanova, A. Makhro, Jue Wang, P. Lipp, L. Kaestner   +4 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Concentration of white blood cells from whole blood by dual centrifugo-pneumatic siphoning with density gradient medium [PDF]

, 2012
Due to the pervasiveness of HIV infections in developing countries there exists a need for a low-cost, user-friendly point-of-care device which can be used to monitor the concentration of T-lymphocytes in the patient’s blood expressing the CD4+ epitope ...
Ducrée, Jens, Glynn, Macdara, Kearney, Sinead M., Kinahan, David J.   +3 more
core  

Action of Hypotonic, Isotonic and Hypertonic Solutions upon the Blood, Muscle and Nerve Tissue Cells of Living Animals [PDF]

, 1922
Ira G. Nichols
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells [PDF]

, 2018
The persistence of HIV reservoirs, including latently infected, resting CD4+ T cells, is the major obstacle to cure HIV infection. CD32a expression was recently reported to mark CD4+ T cells harboring a replication-competent HIV reservoir during ...
Abdel-Mohsen, Mohamed, Betts, Michael R., Buzon, Maria J., Castellvi, Josep, Cox, Kara, Del Rio Estrada, Perla M., Frank, Ian, Genesca, Meritxell, Giron, Leila B., Gonzalez-Navarro, Mauricio, Grau-Exposito, Judith, Hazuda, Daria, Howell, Bonnie, King, Collin T., Kostman, Jay, Kuri-Cervantes, Leticia, Li, Qingsheng, Lynn, Kenneth, Martinez-Picado, Javier, Montaner, Luis J., Mounzer, Karam, Nell, Racheal A., Paiardini, Mirko, Planelles, Vicente, Reyes-Teran, Gustavo, Richman, Douglas, Serra-Peinado, Carla, Spivak, Adam M., Tebas, Pablo, Tomescu, Costin, Vadrevu, Surya Kumari, Vemula, Sai, Wan, Yanmin, Wu, Guoxin   +33 more
core   +1 more source

THE RETICULAR MATERIAL OF DEVELOPING BLOOD CELLS [PDF]

, 1921
E. V. Cowdry
openalex   +1 more source