Results 11 to 20 of about 2,610,022 (268)

An Erg-driven transcriptional program controls B cell lymphopoiesis

Nature Communications, 2020
B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically ...
Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, Warren S. Alexander   +27 more
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Impact of glucocorticoids on short-term and long-term outcomes in patients with relapsed/refractory multiple myeloma treated with CAR-T therapy

Frontiers in Immunology, 2022
BackgroundGlucocorticoids (GCs) are often used to treat cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). The effects of GCs on the efficacy of CAR-T cell treatment in relapsed/refractory multiple myeloma
Xue Wang, Xue Wang, Xue Wang, Yuekun Qi, Yuekun Qi, Yuekun Qi, Hujun Li, Hujun Li, Hujun Li, Fengan Liu, Jiang Cao, Jiang Cao, Jiang Cao, Wei Chen, Wei Chen, Wei Chen, Ying Wang, Ying Wang, Ying Wang, Kunming Qi, Kunming Qi, Kunming Qi, Zhiling Yan, Zhiling Yan, Zhiling Yan, Feng Zhu, Feng Zhu, Feng Zhu, Zhenyu Li, Zhenyu Li, Zhenyu Li, Hai Cheng, Hai Cheng, Hai Cheng, Kailin Xu, Kailin Xu, Kailin Xu   +36 more
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The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

BMC Cancer, 2020
Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required.
Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam, Claire H. Seedhouse   +4 more
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Blood Cells and Blood Cell Development in the Animal Kingdom [PDF]

Annual Review of Cell and Developmental Biology, 2006
Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrate phyla. This has led to a renewed interest regarding homologies between blood cell types and their developmental origin among different animals.
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Immunotherapies targeting GPRC5D in relapsed or refractory multiple myeloma: latest updates from 2022 ASH Annual Meeting

Journal of Hematology & Oncology, 2023
B cell maturation antigen (BCMA)-targeted immunotherapy has shown unprecedented results in the treatment of relapsed or refractory (R/R) multiple myeloma (MM).
Jieyun Xia, Zhenyu Li, Kailin Xu
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A combination of pre-infusion serum ferritin, CRP and IL-6 predicts outcome in relapsed/refractory multiple myeloma patients treated with CAR-T cells

Frontiers in Immunology, 2023
BackgroundChimeric antigen receptor - T (CAR-T) cell therapy has shown remarkable efficacy in patients with relapsed/refractory multiple myeloma (R/R MM).
Yang Liu, Yang Liu, Yang Liu, Xingxing Jie, Xingxing Jie, Xingxing Jie, Li Nian, Li Nian, Li Nian, Ying Wang, Ying Wang, Ying Wang, Congyue Wang, Congyue Wang, Congyue Wang, Jin Ma, Jin Ma, Jin Ma, Jingjing Jiang, Jingjing Jiang, Jingjing Jiang, Qingyun Wu, Qingyun Wu, Qingyun Wu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao, Wei Chen, Wei Chen, Wei Chen, Jiang Cao, Jiang Cao, Jiang Cao, Zhiling Yan, Zhiling Yan, Zhiling Yan, Ming Shi, Hai Cheng, Hai Cheng, Hai Cheng, Feng Zhu, Feng Zhu, Feng Zhu, Wei Sang, Wei Sang, Wei Sang, Depeng Li, Depeng Li, Depeng Li, Chong Chen, Chong Chen, Chong Chen, Kailin Xu, Kailin Xu, Kailin Xu, Zhenyu Li, Zhenyu Li, Zhenyu Li   +57 more
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EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation

Frontiers in Immunology, 2022
IntroductionGraft-versus-host disease (GVHD) damages vascular endothelium. Endothelial progenitor cell (EPC) can differentiate to endothelial cell and promote angiogenesis, but its role in endothelial damage in GVHD is unclear.MethodsIn this study, we ...
Weiwei Wang, Weiwei Wang, Weiwei Wang, Yali Ye, Yali Ye, Yali Ye, Yuwei Du, Yuwei Du, Yuwei Du, Zhengqing Xu, Zhengqing Xu, Zhengqing Xu, Ke Yuan, Ke Yuan, Ke Yuan, Yizhou Wang, Yizhou Wang, Yizhou Wang, Seyram Yao Adzraku, Seyram Yao Adzraku, Seyram Yao Adzraku, Yue Li, Yue Li, Yue Li, Kailin Xu, Kailin Xu, Kailin Xu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao, Wen Ju, Wen Ju, Wen Ju, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng   +35 more
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Autophagy in cells of the blood

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Autophagy is a conserved proteolytic mechanism that degrades cytoplasmic material including cell organelles. The importance of autophagy for cell homeostasis and survival has long been appreciated. Recent data suggest that autophagy is also involved in non-metabolic functions that particularly concern blood cells.
Yousefi, Shida, Simon, Hans-Uwe
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A same‐day assay predicts apoptotic response to combined BCL‐2 and MCL‐1 BH3‐mimetic targeting in multiple myeloma cells

eJHaem, 2021
Recent advances in treatment options for multiple myeloma (MM) have positive impact on patient survival. However, there is a short fall of rapid and reliable assays that can predict patient response to novel agents.
Martin Grundy, Firas Al‐Kaisi, Joanna Cull, Cathy Williams, Dean Smith, Claire H. Seedhouse   +5 more
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THE BLOOD-CELLS IN ANÆMIA. [PDF]

The Lancet, 1881
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