Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease [PDF]
, 2012 A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain.
Rodriguez-Mateos, Ana; id_orcid +33 more
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An Erg-driven transcriptional program controls B cell lymphopoiesis
Nature Communications, 2020 B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically ...
Ashley P. Ng +27 more
doaj +1 more source
A simple model system enabling human CD34+ cells to undertake differentiation towards T cells [PDF]
, 2013 Channelling the development of haematopoietic progenitor cells into T lymphocytes is dependent upon a series of extrinsic prompts whose temporal and spatial sequence is critical for a productive outcome.
B-Lynch Christopher +11 more
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Frontiers in Immunology, 2022 BackgroundGlucocorticoids (GCs) are often used to treat cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). The effects of GCs on the efficacy of CAR-T cell treatment in relapsed/refractory multiple myeloma
Xue Wang +36 more
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Blood Cells and Blood Cell Development in the Animal Kingdom [PDF]
Annual Review of Cell and Developmental Biology, 2006 Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrate phyla. This has led to a renewed interest regarding homologies between blood cell types and their developmental origin among different animals.
openaire +3 more sources
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival [PDF]
, 2012 Recent evidence suggests CML stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from ...
Allan, Elaine K. +18 more
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BMC Cancer, 2020 Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required.
Hayaa Moeed Alhuthali +4 more
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Generation and characterization of erythroid cells from human embryonic stem cells and induced pluripotent stem cells : an overview [PDF]
, 2011 Because of the imbalance in the supply and demand of red blood cells (RBCs), especially for alloimmunized patients or patients with rare blood phenotypes, extensive research has been done to generate therapeutic quantities of mature RBCs from ...
Bönig, Halvard-Björn +5 more
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Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia. [PDF]
, 2011 BACKGROUND\ud \ud Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process.
Fried, Michal +7 more
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Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]
, 2012 Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
McCaig, Alison M. +14 more
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