Results 221 to 230 of about 4,253,616 (306)

Age-dependent neuroinflammatory effects of red blood cells and their exosomes in a human brain-on-chip model. [PDF]

Blood Red Cells Iron
Mehta-Doshi A, Tsu BL, Sauceda C, Kairs SN, Liu J, Rai J, Whisenant T, Sasik R, Barnes CA, Ban DK, Gonzalez DJ, Aran K.   +11 more
europepmc   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Computational Microscopy Reveals Compound-Specific Flickering Phenotypes of Red Blood Cells Under Flavonoid Exposure. [PDF]

Membranes (Basel)
Pozo-Rojas CD, Montalvo-Quirós S, Rufo L, Bueno JM, Calero M, Monroy F, Herráez-Aguilar D.   +6 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Advances in the characterization of in vitro-generated red blood cells: from biophysical properties to functional applications. [PDF]

Stem Cell Res Ther
Jang Y, Eom YJ, Gwak SH, Koh Y, Han J, Rim YA, Nam Y, Ju JH.   +7 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Peripheral Blood Cells and Clinical Profiles as Biomarkers for Pain Detection in Palliative Care Patients. [PDF]

Biomedicines
Ribeiro H, Alves R, Jorge J, Oliveiros B, Gaspar T, Rodrigues I, Neves JR, Silva JB, Neves AP, Sarmento-Ribeiro AB, Dourado M, Gonçalves AC, Andrade JP.   +12 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Anthracyclines effect on mitochondrial function and biogenesis in normal blood cells of hodgkin lymphoma patients. [PDF]

Sci Rep
Sambuceti G, Coco S, Cossu V, Carta S, Lanfranchi F, Ghiggi C, Ceresa D, Pana K, Colombo M, Marconi S, Ghelardoni M, Losacco S, Vitale F, Chiesa S, Orengo AM, Bauckneht M, Angelucci E, Marini C.   +17 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source