Results 231 to 240 of about 9,259,664 (317)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Glycine receptors in circulating white blood cells regulated by neuroinflammation. [PDF]

Front Immunol
Thakur V, Chokpapone YM, Mishra R, Evbuomwan O, Lopez L, Guerrero C, Chavez A, Carrizales I, Rodriguez BJ, Lavezo J, Rodriguez GJ, Dou H.   +11 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Peripheral blood cells and immune checkpoint inhibitor-associated myocarditis: a retrospective clinical study with pharmacovigilance and single-cell analysis. [PDF]

Front Immunol
Li Z, He J, Ma Z, Liu P, Guan Z, Du S, Yao T, Liu G, Liu J, Guo L, Zhang Y, Wang T, Li M, Ma J.   +13 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Exploration and practice: New integration of cellular therapy and hematopoietic stem cell transplantation

Chinese Medical Journal
Ruihao Huang, Xi Zhang, Yanjie Yin
doaj   +1 more source

A Vortioxetine-Glycyrrhizic Acid Supramolecular Complex: Synthesis and Cellular Effects on Microglial and Blood Cells Under Inflammatory and Glucocorticoid Challenge. [PDF]

Biomedicines
Khantakova JN, Meteleva ES, Ryabushkina YA, Polyakov NE, Degtyareva AO, Salman R, Dushkin AV, Bondar NP.   +7 more
europepmc   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

PolyJet 3D-printed microfluidic device that integrates hydrodynamic focusing of red blood cells and detection of ATP release.

Anal Methods
Singhateh M, Azibere S, Sprague RS, Karunarathne A, Liyanage S, Martin RS.   +5 more
europepmc   +1 more source

Automated method for determining the zeta potential of red blood cells via motion tracking in microelectrophoresis. [PDF]

Biochem Biophys Rep
Borikov O, Berest V, Liadov D.
europepmc   +1 more source