Results 91 to 100 of about 1,887,489 (360)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Deep learning-based label-free hematology analysis framework using optical diffraction tomography

open access: yesHeliyon, 2023
Hematology analysis, a common clinical test for screening various diseases, has conventionally required a chemical staining process that is time-consuming and labor-intensive.
Dongmin Ryu   +7 more
doaj  

Leukemia detection based on microscopic blood smear images using deep learning [PDF]

open access: yesarXiv, 2022
In this paper we discuss a new method for detecting leukemia in microscopic blood smear images using deep neural networks to diagnose leukemia early in blood. leukemia is considered one of the most dangerous mortality causes for a human being, the traditional process of diagnosis of leukemia in blood is complex, costly, and time-consuming, so patients ...
arxiv  

Chemical enhancement of soil based footwear impressions on fabric [PDF]

open access: yes, 2012
This study investigates the enhancement of footwear impressions prepared with soils from different locations on a variety of fabric surfaces with different morphology.
Bandey, Helen   +3 more
core   +2 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

open access: yeseLife, 2015
Analysis of brain ultrastructure using electron microscopy typically relies on chemical fixation. However, this is known to cause significant tissue distortion including a reduction in the extracellular space.
Natalya Korogod   +2 more
doaj   +1 more source

Towards a Mathematical Model for the Solidification and Rupture of Blood in Stenosed Arteries [PDF]

open access: yesarXiv, 2020
In this paper, we present a mathematical and numerical model for blood solidification and its rupture in stenosed arteries. The interaction between the blood flow and an existing stenosis in the arterial wall is modeled as a three dimensional fluid-structure interaction problem.
arxiv  

Reconstructing the Hemodynamic Response Function via a Bimodal Transformer [PDF]

open access: yesarXiv, 2023
The relationship between blood flow and neuronal activity is widely recognized, with blood flow frequently serving as a surrogate for neuronal activity in fMRI studies. At the microscopic level, neuronal activity has been shown to influence blood flow in nearby blood vessels.
arxiv  

Measuring Blood Glucose Concentrations in Photometric Glucometers Requiring Very Small Sample Volumes

open access: yes, 2016
Glucometers present an important self-monitoring tool for diabetes patients and therefore must exhibit high accu- racy as well as good usability features.
Demitri, Nevine, Zoubir, Abdelhak M.
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

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