Results 61 to 70 of about 5,111,387 (310)

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Nature Communications, 2016
Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the crosstalk between coagulation and immunity in CNS autoimmunity.
K. Göbel, Susann Pankratz, Chloi-Magdalini Asaridou, A. Herrmann, S. Bittner, M. Merker, T. Ruck, Sarah Glumm, F. Langhauser, P. Kraft, T. Krug, J. Breuer, M. Herold, C. Gross, D. Beckmann, A. Korb-Pap, Michael K. Schuhmann, S. Kuerten, I. Mitroulis, C. Ruppert, M. Nolte, C. Panousis, L. Klotz, B. Kehrel, T. Korn, H. Langer, T. Pap, B. Nieswandt, H. Wiendl, T. Chavakis, C. Kleinschnitz, S. Meuth   +31 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Successful Mother and Neonate Outcome for a Woman with Essential Thrombocytosis and FV Leiden Heterozygosity

Case Reports in Obstetrics and Gynecology, 2016
Essential thrombocytosis (ET) and FV Leiden heterozygosity represent an acquired and hereditable hypercoagulable state, respectively. An uncommon case of coexistence of ET and FV Leiden heterozygosity in a 36-year-old pregnant woman and her successful ...
Marianna Politou, Serena Valsami, Irontianta Gkorezi-Ntavela, Vasilios Telonis, Efrosyni Merkouri, Panagiotis Christopoulos   +5 more
doaj   +1 more source

Dental surgical care in blood dyscrasias patients: an epidemiological study

RGO: Revista Gaúcha de Odontologia, 2021
Introduction: In Brazil, about 18.500 people have some kind of hereditary coagulopathy. In combination, the increase in life expectancy has led to an increasingly frequent presence of older people in medical offices. These patients make use of many drugs,
Lorenzzo De Angeli CESCONETTO, Luiz Henrique Soares TORRES, Renata Pittella CANÇADO, André Alberto Camara PUPPIN   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

Blood, 2020
Publisher's Note: There is a Blood Commentary on this article in this issue.
Hanny T Al-Samkari, R. K. Karp Leaf, W. Dzik, J. Carlson, Annemarie E. Fogerty, A. Waheed, Katayoon Goodarzi, Pavan K. Bendapudi, L. Bornikova, Shruti Gupta, D. Leaf, D. Kuter, R. Rosovsky   +12 more
semanticscholar   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Hydrodynamical activation of blood coagulation in stenosed vessels. Theoretical analysis [PDF]

Компьютерные исследования и моделирование, 2012
The mechanisms of hydrodynamical activation of blood coagulation system are investigated in stenosed vessels for a wide range of Reynolds number values (from 10 up to 500).
Aleksey Sergeevich Rukhlenko, Ksenia Evgenyevna Zlobina, Georgy Theodorovich Guria   +2 more
doaj   +1 more source

Assessing blood clotting and coagulation factors in mice

Current Protocols in Mouse Biology, 2019
The mammalian blood coagulation system was designed to restrict blood loss due to injury as well as keep the blood fluid within the blood vessels of the organism.
Marisa A. Brake, L. Ivanciu, S. Maroney, N. Martinez, A. Mast, Randal J Westrick   +5 more
semanticscholar   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source