Results 201 to 210 of about 218,057 (351)

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

Explainable AI unravels sepsis heterogeneity via coagulation-inflammation profiles for prognosis and stratification. [PDF]

Nat Commun
Zhu L, Chen Z, Zhang H, Chen H, Liu L, Yu W, Wu K, Chen Y, Tao X, Yu Z, Shi L, Wang J, Zhang F, Shen J, Liu F, Hu C, Ren Y, Liu TM, Luo Y, Guo F, Niu B.   +20 more
europepmc   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Thromboelastography in ruptured abdominal aortic aneurysm management: lessons from vascular, cardiac, and trauma surgery. [PDF]

Front Cardiovasc Med
Gniedziejko M, Halman J, Kimilu N, Folwarski M, Siemiński M.   +4 more
europepmc   +1 more source

Prediction of embolism in patient with mitral stenosis studied by two-dimensional echocardiography and blood coagulation tests.

, 1989
Masahiro Yasaka, Kunio Miyatake, Mayumi Mitani, Shintaro Beppu, Seiki Nagata, Takenori Yamaguchi, Teruo Omae   +6 more
openalex   +2 more sources

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Endobronchial Recurrence of Renal Cell Carcinoma 12 Years After Nephrectomy: A Rare Case Treated With Microwave Coagulation Therapy. [PDF]

Cureus
Nakano H, Sugimoto Y, Aoki R, Tsukasa Y, Takeuti T, Yamamoto T, Abe S, Takayama M.   +7 more
europepmc   +1 more source

The Effects of Sodium Fructose Diphosphate on Blood Coagulation Reaction Time and Plasma Coagulation Factor Activity Tests in vitro

Yalong Zhang, Xingguo Zhong, Lin Zhou, Ning He, Yuan Fang, Tongqing Chen   +5 more
openalex   +1 more source

The regulation of blood coagulation by protein S in the absence of activated protein C : from test tube to plasma [PDF]

, 2005
Rory R. Koenen
openalex   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source