Results 21 to 30 of about 135,563 (308)
Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography
Platelets, 2018 A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot +5 more
doaj +1 more source
Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease
Diagnostics, 2022 Over the last decades, individualized approaches and a better understanding of coagulopathy complexity in end-stage liver disease (ESLD) patients has evolved.
Tina Tomić Mahečić +8 more
doaj +1 more source
The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro. [PDF]
PLoS ONE, 2016 Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential ...
Valery Golderman +8 more
doaj +1 more source
Viscoelastic Tests in the Evaluation of Haemostasis Disturbances in SARS-CoV2 Infection
Acta Médica Portuguesa, 2021 COVID-19 associated coagulopathy is a dysfunction of severe SARS-CoV-2 infection, characterized by significantly increased fibrinogen, D-dimer and C reactive protein and normal to near-normal prothrombin time, activated partial thromboplastin time and ...
Anabela Rodrigues +4 more
doaj +1 more source
Early and individualized goal-directed therapy for trauma-induced coagulopathy
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2012 Severe trauma-related bleeding is associated with high mortality. Standard coagulation tests provide limited information on the underlying coagulation disorder.
Schöchl Herbert +4 more
doaj +1 more source
Comparison of standard coagulation testing with thromboelastometry tests in cardiac surgery [PDF]
Journal of Cardiovascular and Thoracic Research, 2019 Introduction: According to the several evidences, using thromboelastometry as a point of care test can be effective in reduction in blood loss and transfusion requirements in cardiac surgeries.
Elham Khalaf- Adeli +3 more
doaj +1 more source
Classical and Point-of-Care tests in severe hemorrhage management
AboutOpen, 2022 Hemorrhage is defined as an acute loss of blood from the cardiovascular system. The hemostatic cascade (comprising the vasculature, coagulation factors, the fibrinolytic and the platelet systems) is the physiological mechanism meant to control this ...
Paolo Simioni
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2020 Background and Objective: One of the health indices in human is normality of the number and size of blood cells. The purpose of this study was to screen for bleeding and coagulation disorders among the patients in oral medicine department of Yazd dental ...
Hoda Farmanara, Hakimeh Ahadian
doaj
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source