Results 91 to 100 of about 11,652,656 (310)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Prion diseases are efficiently transmitted by blood transfusion in sheep [PDF]

, 2008
The emergence of variant Creutzfeld-Jakob disease, following on from the bovine spongiform encephalopathy (BSE) epidemic, led to concerns about the potential risk of iatrogenic transmission of disease by blood transfusion and the introduction of costly ...
Foster, J., Hunter, N., Goldmann, W., Chong, A., Gonzalez, L., Siso, S., Houston, F., McCutcheon, S., Jeffrey, M.   +8 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

"Cash-for-Blood" Companies Still Thriving in US

, 1998
Unlike Canada's voluntary blood-collection system, the US system routinely makes use of donations from paid donors. Milan Korcok reports that this is starting to cause some concern, since infection levels tend to be higher among those who are paid for ...
Korcok, Milan
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Blood collection [PDF]

ISBT Science Series, 2008
openaire   +3 more sources

More than a drop of blood: the paradigm shift of a large-volume capillary sample for point-of-care clinical diagnostics

Journal of Clinical Microbiology
The validation of a large-volume fingerstick sample for the newly Food and Drug Administration-authorized Xpert HCV test has created an important precedent for the use of a large-volume capillary blood sample for point-of-care (POC) testing. This advance
Gregory L. Damhorst, Anuradha Rao, Nira R. Pollock   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Surveillance of HIV-1 genetic subtypes and diversity in the US blood supply

, 2000
BACKGROUND: Recent reports of variant (non-subtype B) HIV infections in US populations have raised concerns about the sensitivity of subtype B virus-based donor screening and diagnostic assays.
Finlayson, T., Gwinn, M., Busch, M. P., Sullivan, M. T., Oliveira, C. F. de, Machado, D. M., Kessler, D., Lackritz, E. M., Operskalski, E. A., Williams, A. E., Mosley, J. W., Diaz, R. S.   +11 more
core   +1 more source

Advancing Lead Exposure Studies in Remote Settings: Method Development and Application of Lead Stable Isotope Analysis in Dried Blood Spots from Suriname, South America

Toxics
Background: Lead (Pb) exposure remains a major global health issue, and Pb stable isotope ratio analysis is a powerful tool for identifying potential exposure sources.
Manasi Simhan, Sean R. Scott, Martin M. Shafer, Jenny N. Poynter, Gaitree K. Baldewsingh, Wilco C. W. R. Zijlmans, Anisma R. Gokoel, Maureen Y. Lichtveld, Jeffrey K. Wickliffe, Shannon M. Sullivan   +9 more
doaj   +1 more source