Results 71 to 80 of about 2,005,926 (345)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus). [PDF]

, 2020
Psychosocial stressors - life events that challenge social support and relationships - represent powerful risk factors for human disease; included amongst these events are relocation, isolation and displacement.
Benjamin, Cassandra, Coppola, Giovanni, Freimer, Nelson B, He, Tianyu, Jasinska, Anna J, Jentsch, James D, Lee, Jen Chieh, Newton, Maurice, Pandrea, Ivona   +8 more
core  

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Eigenhearts for diagnosis of congestive heart failure (CHF) [PDF]

, 2006
Common cardiac diseases such as cardio-myopathy, coronary artery diseases, and valve diseases, result in abnormal myocardial movement, which could eventually lead to heart failure, also called congestive heart failure (CHF). CHF is a disease in which the
Ahanathapillai, Vijayalakshmi, Hamilton, David   +1 more
core   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Non-hematopoietic essential functions of bone marrow cells: a review of scientific and clinical literature and rationale for treating bone defects

Orthopedic Reviews, 2015
Hematopoiesis as the only essential function of bone marrow cells has been challenged for several decades through basic science (in vitro and in vivo) and clinical data.
David B. Harrell, Eugenio Caradonna, Laura Mazzucco, Rosmarie Gudenus, Berthold Amann, Vaclav Prochazka, Peter V. Giannoudis, Christian Hendrich, Marcus Jäger, Rüdiger Krauspe, Philippe Hernigou   +10 more
doaj   +1 more source

Allogeneic blood components [PDF]

Transfusion Alternatives in Transfusion Medicine, 2008
SUMMARYThere are no absolute recognized clinical indications for the transfusion of whole blood, and therefore blood is separated into its components (red cells, platelets and plasma) prior to transfusion. Blood components can be either produced from whole‐blood donations or collected directly from the donor by apheresis technology.
Sheila Maclennan, Rebecca Cardigan
openaire   +2 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Blood component therapy: Which, when and how much

Journal of Anaesthesiology Clinical Pharmacology, 2011
Blood transfusion refers to the perioperative administration of blood and blood components. Adherence to proper indications for blood component therapy is essential because of its potential adverse effects and costs of transfusion.
Rajesh Chand Arya, G S Wander, Pankaj Gupta   +2 more
doaj   +1 more source