Results 161 to 170 of about 532,140 (257)

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

A prospective treatment for sepsis

Drug Design, Development and Therapy, 2015
Mohammad Rashid Shahidi Bonjar,1 Leyla Shahidi Bonjar2 1School of Dentistry, 2College of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Abstract: The present paper proposes a prospective auxiliary treatment for sepsis.
Shahidi Bonjar MR, Shahidi Bonjar L
doaj  

If it does not help, it might hurt: Pharmacodynamics of a second IVIg course in Guillain–Barré syndrome

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of a single and a second IVIg dose (SID) in patients with GBS.
Sander J. van Tilburg, Ruth Huizinga, Krista Kuitwaard, Sebastiaan D.T. Sassen, Christa Walgaard, Pieter A. van Doorn, Bart C. Jacobs, Birgit C.P Koch   +7 more
wiley   +1 more source

Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP‐43 A and B

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations. It is uncertain whether syndromic or imaging features previously associated with these patient groups are subtype or genotype specific.
Sean Coulborn, Rhiana Schafer, Ashlin R. K. Roy, Andrzej Sokolowski, Noah G. Cryns, Dana Leichter, Argentina Lario Lago, Eliana Marisa Ramos, Yann Cobigo, Salvatore Spina, Lea T. Grinberg, Daniel H. Geschwind, Maria L. Gorno‐Tempini, Joel H. Kramer, Howard J. Rosen, Bruce L. Miller, William W. Seeley, David C. Perry   +17 more
wiley   +1 more source

Cerebral Amyloid Angiopathy Is Associated With Higher R2 Relaxation Rate: An MRI and Pathology Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral amyloid angiopathy (CAA) involves β‐amyloid deposition in the walls of cortical and leptomeningeal small vessels. Transverse relaxation rate (R2) is a major source of contrast in MRI. This study tested the hypothesis that CAA is associated with R2, extracted the spatial pattern of CAA‐related R2 abnormalities, and evaluated ...
Md Tahmid Yasar, Arnold M. Evia, Mahir Tazwar, Sue E. Leurgans, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +6 more
wiley   +1 more source

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling, Johannes P. van Dijk, Prisca R. Bauer, Roland D. Thijs, Josemir W. Sander, Machiel Zwarts, Gerhard H. Visser   +6 more
wiley   +1 more source

The mechanisms of leukocyte removal by filtration [PDF]

, 1995
Absolom, Absolom, Absolom, Absolom, Absolom, Adin, Al, Alt, Amer, Anderson, Anderson, Anton Bruil, Aplin, Baker, Bale, Ballard, Barber, Blackshear, Blackshear, Bowden, Brand, Breillat, Brock, Brown, Bruil, Bruil, Bruil, Bruil, Bruil, Bruil, Bruil, Bruil, Brånemark, Böck, Cain, Callaerts, Carreno, Cassell, Castner, Chang, Chaplin, Cheng, Chenoweth, Chien, Chien, Clarke, Cokelet, Conti, Crowley, Crumpton, Curtis, Curtis, Curtis, Curtis, Curtis, de Graan-Hentzen, Dekker, Diepenhorst, Diepenhorst, Diepenhorst, Dolowy, Eernisse, Eisen, Eisenfield, Elwing, Ertel, Faint, Fenton, Fiore, Fleming, Forrester, Franzini, Friedman, Garcia-Pardo, Garvin, Gingell, Gingell, Goldsmith, Goldstein, Grasel, Greenwalt, Grinnell, Grinnell, Groth, Guidoin, Halperin, Hamburger, Harkes, Hed, Heddle, Heertjes, Hertz, Herzig, Herzlinger, Hoffstein, Hoover, Horbett, Hudson, Hynes, Ikeda, Ito, Ives, Ives, Ives, Iwasaki, James, Jan Feijen, Jungi, Kataoka, Kataoka, Kataoka, Kayashima, Kazatchkine, Kickler, Kikugawa, Kishimoto, Klebe, Klemperer, Klock, Kottke-Marchant, Kvarstein, Lamvik, Lang, Larson, Law, Lee, Lelah, Lichtman, Lichtman, Lim, Lucas, MacGregor, Mackie, Mackrle, Marchant, Maruyama, Matharasan, Matsuda, Matsumoto, Mayrovitz, Meryman, Meryman, Meryman, Mijovic, Morley, Moroson, Mutharasan, Müller-Eberhard, Netter, Neumann, Neumann, Neumann, Nishimura, Nobis, Okano, Okano, Okano, Olijslager, Oshima, Owewn, Pall, Payne, Perkins, Perkins, Pierschbacher, Pietersz, Pikul, Polliack, Predecki, Prins, Prins, Ramarao, Ramsey, Randall, Rasp, Rasp, Rebulla, Reesink, Reverberi, Rich, Rinehart, Roos, Saarinnen, Sadoff, Schiffer, Schmalzer, Schmid-Schönbein, Schmid-Schönbein, Schmid-Schönbein, Schmid-Schönbein, Sevast'ianov, Sharma, Shepard, Sherbet, Shimizu, Sirchia, Sirchia, Sirchia, Skalak, Skalak, Slichter, Smith, Snyder, Snyder, Snyder, Snyder, Snyder, Spilizewski, Springer, Srinivasan, Srinivasan, Steneker, Steneker, Steneker, Swank, Takahara, Takaoka, Takemoto, Tetta, Tien, Tom Beugeling, Treleaven, Trenor, Tsurumi, Uchida, Uda, Unarska, Vakkila, van Damme, van Kampen, van Oss, Vanherweghem, Vassar, Vigneswaran, von Recum, Vroman, Ward, Ward, Watanabe, Wenz, Wenz, Wenz, Wenz, Wenz, Willem G. van Aken, Yeo, Yui, Yui, Zaiss, Zingg   +249 more
core   +2 more sources

EEG Spectral Exponents and Visual Chirp Responses Mirror Anti‐Seizure Medication Load in Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Quantitative markers of cortical excitability may help identify responders to anti‐seizure medications (ASMs). We studied the relationship between ASM load and two electroencephalography (EEG) markers of cortical excitability in people with refractory epilepsy. Methods We included individuals with refractory focal epilepsy undergoing
Silvano R. Gefferie, Arthur R. van Nieuw Amerongen, Gerhard H. Visser, Maeike Zijlmans, Else A. Tolner, Mark van de Ruit, Arn M. J. M. van den Maagdenberg, Roland D. Thijs   +7 more
wiley   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source