Results 51 to 60 of about 5,986,563 (283)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Resilient, Non-neuronal Source of the Spatiotemporal Lag Structure Detected by BOLD Signal-Based Blood Flow Tracking

Frontiers in Neuroscience, 2017
Recent evidence has suggested that blood oxygenation level-dependent (BOLD) signals convey information about brain circulation via low frequency oscillation of systemic origin (sLFO) that travels through the vascular structure (“lag mapping”).
Toshihiko Aso, Guanhua Jiang, Shin-ichi Urayama, Hidenao Fukuyama   +3 more
doaj   +1 more source

Terahertz Time-Domain Spectroscopy of Glioma Patient Blood Plasma: Diagnosis and Treatment

Applied Sciences, 2023
Gliomas, one of the most severe malignant tumors of the central nervous system, have a high mortality rate and an increased risk of recurrence. Therefore, early glioma diagnosis and the control of treatment have great significance.
Olga Cherkasova, Denis Vrazhnov, Anastasia Knyazkova, Maria Konnikova, Evgeny Stupak, Vadim Glotov, Vyacheslav Stupak, Nazar Nikolaev, Andrey Paulish, Yan Peng, Yury Kistenev, Alexander Shkurinov   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The chlorite-based drug WF10 constantly reduces hemoglobin A1c values and improves glucose control in diabetes patients with severe foot syndrome

Journal of Clinical & Translational Endocrinology, 2016
Aims: The intravenous application of the chlorite-based drug solution WF10 is known to improve wound healing in patients with diabetic foot syndrome.
Paiboon Maraprygsavan, Jarasporn Mongkolsuk, Juergen Arnhold, Friedrich-Wilhelm Kuehne   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Leukoreduced blood components: Advantages and strategies for its implementation in developing countries

Asian Journal of Transfusion Science, 2010
Removal of leucocytes from various blood products has been shown to minimize Febrile nonhemolytic transfusion reactions, HLA alloimmunization, platelet refractoriness in multitransfused patients and prevention of transmission of leukotropic viruses such ...
Sharma R, Marwaha Neelam
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Synthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification. [PDF]

, 2009
Crosslinked polystyrene co-divinylbenzene adsorbent microspheres with median diameters between 40 and 300 μm, with an enhanced proportion of mesopores in the range 4–10 nm, have been synthesized using a membrane emulsification technique.
Trochimczuk, Andrzej W., D.J. Malik, Malik, Danish Javed, Chris Webb (7127804), R.G. Holdich, C. Webb, Dale, James A., Iain Roche (7127942), G.L. Warwick, N.A. Hoenich (7128515), G.L. Warwick (7128506), Danish Malik (1254321), Richard Holdich (1253271), J.J. Ramsden (7128503), J.A. Dale (7128512), David Williams (1248024), Warwick, Graham L., Roche, I., Holdich, Richard G., I. Roche, Williams, David John, J.A. Dale, A.W. Trochimczuk, N.A. Hoenich, J.J. Ramsden, D.J. Williams, Hoenich, Nicholas Andrew, Webb, C., Ramsden, Jeremy J., Andrzej W. Trochimczuk (7128509)   +29 more
core   +1 more source