Results 51 to 60 of about 7,178,224 (293)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Synthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification. [PDF]

, 2009
Crosslinked polystyrene co-divinylbenzene adsorbent microspheres with median diameters between 40 and 300 μm, with an enhanced proportion of mesopores in the range 4–10 nm, have been synthesized using a membrane emulsification technique.
Trochimczuk, Andrzej W., D.J. Malik, Malik, Danish Javed, Chris Webb (7127804), R.G. Holdich, C. Webb, Dale, James A., Iain Roche (7127942), G.L. Warwick, N.A. Hoenich (7128515), G.L. Warwick (7128506), Danish Malik (1254321), Richard Holdich (1253271), J.J. Ramsden (7128503), J.A. Dale (7128512), David Williams (1248024), Warwick, Graham L., Roche, I., Holdich, Richard G., I. Roche, Williams, David John, J.A. Dale, A.W. Trochimczuk, N.A. Hoenich, J.J. Ramsden, D.J. Williams, Hoenich, Nicholas Andrew, Ramsden, Jeremy J., Andrzej W. Trochimczuk (7128509), Webb, Carolyn   +29 more
core   +1 more source

The chlorite-based drug WF10 constantly reduces hemoglobin A1c values and improves glucose control in diabetes patients with severe foot syndrome

Journal of Clinical & Translational Endocrinology, 2016
Aims: The intravenous application of the chlorite-based drug solution WF10 is known to improve wound healing in patients with diabetic foot syndrome.
Paiboon Maraprygsavan, Jarasporn Mongkolsuk, Juergen Arnhold, Friedrich-Wilhelm Kuehne   +3 more
doaj   +1 more source

Removal of the skin blood flow artifact in functional near-infrared spectroscopic imaging data through independent component analysis

Journal of Biomedical Optics, 2007
We investigate whether the functional near-infrared spectroscopic (fNIRS) signal includes a signal from the changing skin blood flow. During a locomotor task on a treadmill, changes in the hemodynamic response in the front-parietal area of healthy human subjects are simultaneously recorded using an fNIRS imaging system and a laser Doppler tissue blood ...
Satoru, Kohno, Ichiro, Miyai, Akitoshi, Seiyama, Ichiro, Oda, Akihiro, Ishikawa, Shoichi, Tsuneishi, Takashi, Amita, Koji, Shimizu   +7 more
openaire   +2 more sources

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Leukoreduced blood components: Advantages and strategies for its implementation in developing countries

Asian Journal of Transfusion Science, 2010
Removal of leucocytes from various blood products has been shown to minimize Febrile nonhemolytic transfusion reactions, HLA alloimmunization, platelet refractoriness in multitransfused patients and prevention of transmission of leukotropic viruses such ...
Sharma R, Marwaha Neelam
doaj  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

High abundant protein removal from rodent blood for biomarker discovery [PDF]

, 2014
In order to realize the goal of stratified and/or personalized medicine in the clinic, significant advances in the field of biomarker discovery are necessary.
Eldridge, Angela, Haudenschild, Dominik R, Chromy, Brett A, Lein, Pamela J   +3 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source