Results 51 to 60 of about 234,142 (282)

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

Terahertz Time-Domain Spectroscopy of Glioma Patient Blood Plasma: Diagnosis and Treatment

Applied Sciences, 2023
Gliomas, one of the most severe malignant tumors of the central nervous system, have a high mortality rate and an increased risk of recurrence. Therefore, early glioma diagnosis and the control of treatment have great significance.
Olga Cherkasova, Denis Vrazhnov, Anastasia Knyazkova, Maria Konnikova, Evgeny Stupak, Vadim Glotov, Vyacheslav Stupak, Nazar Nikolaev, Andrey Paulish, Yan Peng, Yury Kistenev, Alexander Shkurinov   +11 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Resilient, Non-neuronal Source of the Spatiotemporal Lag Structure Detected by BOLD Signal-Based Blood Flow Tracking

Frontiers in Neuroscience, 2017
Recent evidence has suggested that blood oxygenation level-dependent (BOLD) signals convey information about brain circulation via low frequency oscillation of systemic origin (sLFO) that travels through the vascular structure (“lag mapping”).
Toshihiko Aso, Guanhua Jiang, Shin-ichi Urayama, Hidenao Fukuyama   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Noble, M., Drake-Holland, A.J., Belcher, P.R.   +2 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The chlorite-based drug WF10 constantly reduces hemoglobin A1c values and improves glucose control in diabetes patients with severe foot syndrome

Journal of Clinical & Translational Endocrinology, 2016
Aims: The intravenous application of the chlorite-based drug solution WF10 is known to improve wound healing in patients with diabetic foot syndrome.
Paiboon Maraprygsavan, Jarasporn Mongkolsuk, Juergen Arnhold, Friedrich-Wilhelm Kuehne   +3 more
doaj   +1 more source

A novel two-component signal transduction system in propionibacterium acnes and its association with a putative extracellular signalling peptide [PDF]

, 2011
Propionibacterium acnes, a resident micro-organism of human skin, is thought to be involved in the development of inflammatory acne, which is an exclusive human disease affecting more than 80% of the whole population. Quorum sensing is the regulation of
Guan, Shuang
core