Results 71 to 80 of about 7,178,224 (293)

The Complex Web of Othernesses in Marcus Gardley’s Play The Road Weeps, the Well Runs Dry

Societies, 2018
Marcus Gardley’s play The Road Weeps, the Well Runs Dry (2013) traces the development of a Black Seminole community in the Indian Territory from 1850 to 1866, with occasional flashbacks to the days of the Seminoles’ removal from Florida ...
Claus-Peter Neumann
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK

Неотложная медицинская помощь, 2016
. The key component of the sepsis pathogenesis is the gram-negative bacteria endotoxin. It is a lipopolysaccharide of the bacterial wall, which circulation in the bloodstream results in unlimited activation of some biological systems, causing serious ...
V. V. Kirkovsky, I. G. Kolesnikova, D. S. Tretyak, E. L. Sedjolkina   +3 more
doaj  

THE CONSTRUCTION OF PHYSICAL REHABILITATION PROGRAMS IN THE PREOPERATIVE PERIOD FOR PATIENTS THAT WILL REMOVE OF INTERVERTEBRAL DISC’ PROLAPSE IN THE LUMBAR SPINE

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2014
The ineffectiveness of conservative treatment will make the need for surgery in 4-5% of patients suffering from low back pain with hernias of the lumbar and sacral spine.
E.B. Lazarieva, V.V. Kormiltsev, Krzysztof Prusik, Mirosława Cieślicka   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

STUDY OF MICROCIRCULATION OF THE EYEBALL IN THE SURGICAL TREATMENT OF INTRAOCULAR HEMORRHAGE

Кубанский научный медицинский вестник, 2014
This article describes changes in the microcirculation of the eyeball in patients with hemophthalmus during vitrectomy. We examined 24 patients who underwent vitrectomy, according to testimory local lasercoagulation of retinal vessels.
A. V. Malyshev, V. N. Trubiun, S. M. Makkaeva, S. V. Janchenko, Z. ZH. Alrashid, Y. A. Gusev, L. Sh. Ramazanova   +6 more
doaj  

Two-stage treatment of hip periprosthetic joint infection complicated with retroperitoneal urinary bladder defect

Гений oртопедии, 2021
. Purpose To demonstrate the need for a multidisciplinary approach to the treatment of patients with deep periprosthetic joint infection (PJI) and emphasize the importance of preoperative preparation and well-coordinated work of related specialists ...
Sergei T. Ivanian, Stanislav V. Basov, Nikolai O. Gritsuk, Vladimir A. Pronin, Sergei N. Tikhonenko   +4 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease [PDF]

, 2012
A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain.
Rodriguez-Mateos, Ana; id_orcid, Wolters, Dirk, Heiß, Christian, Rodriguez Mateos, Ana, Krenz, Thomas, Kuhnle, G. G. C., Cortese-Krott, Miriam M, Rodriguez-Mateos, Ana, Kelm, Malte, Cortese-Knott, Miriam M., Feelisch, Martin, Rodriguez-Mateos, Z, Kroncke, K.-D., Kröncke, Klaus-Dietrich, Sansone, R., Kuhnle, Gunter G. C., Kelm, M., Heiss, C., Krisp, C., Sansone, Roberto, Horn, P., Feelisch, M., Horn, Patrick, Krisp, Christoph, Krenz, T., Hogg, N., Kuhnle, Gunter, Kuhnle, Gunter G.C., Thasian-Sivarajah, S., Thasian-Sivarajah, Sivatharsini, Wolters, D., Cortese-Krott, Miriam M., Hogg, Neil, Cortese-Krott, M. M.   +33 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source