Results 61 to 70 of about 112,813 (357)

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Reducing blood wastage through introduction of a transfusion team

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background In the intense setting of reception and resuscitation of critically bleeding patients, wastage of up to 10% of blood components occur, commonly due to prolonged breaks in the cold chain. Additionally, some transfusions may be avoidable.
Biswadev Mitra, Ruby Garland, Jackson Catalano, Gerard O’Reilly, Alexandra Nevill   +4 more
doaj   +1 more source

Quality Review of Irradiated Cellular Blood Product Orders [PDF]

, 2017
Objectives: Our goal is to educate house staff on the indications for irradiated blood products. We hope to reduce the number of inappropriate irradiation orders to less than 50% of the total orders for irradiated blood products and to be followed up ...
Grzywinski, Matthew, Ly, MD, Vandy
core   +1 more source

Sublytic Terminal Complement Components Induce Eryptosis in Autoimmune Haemolytic Anaemia Related to IgM Autoantibodies [PDF]

, 2019
BACKGROUND/AIMS: Eryptosis, the suicidal death of red blood cells (RBCs), is characterized by phosphatidylserine (PS) exposure at the cell surface. It can be catalysed by a variety of abnormal conditions and diseases.
Balola, Abdelwahab Hassan Ahmed, Bartolmäs, Thilo, Mayer, Beate, Salama, Abdulgabar   +3 more
core   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Modelling very large complex systems using distributed simulation: A pilot study in a healthcare setting [PDF]

, 2006
Modern manufacturing supply chains are hugely complex and like all stochastic systems, can benefit from simulation. Unfortunately supply chain systems often result in massively large and complicated models, which even today’s powerful computers cannot ...
Brailsford, S, Katsaliaki, K, Mustafee, N, Taylor, SJE   +3 more
core   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Blood components requirement in Brazilian dengue outbreaks: A retrospective analysis between 2008 to 2019

Hematology, Transfusion and Cell Therapy
Introduction: Dengue is the most fatal virus disease spread by mosquito bites and Aedes aegypti is the main transmitting agent. It is an endemic disease in the tropical and subtropical regions, currently affecting more than 100 countries.
Deivide de Sousa Oliveira, Daniel Girão Britto, Gabriella Fidelis de Sá, Ana Carolina Nogueira Rocha Lima, João Victor Araújo Silva, Antonio Vinícius Barros de Araújo, Rejane Cavalcante Rebelo, Larissa Ciarlini Varandas Sales, Marcus Fábio Tavares de Abreu, Ednardo Ramos de Meneses   +9 more
doaj   +1 more source

Studies on the Hemoglobin of Cooley's Anemia and Cooley's Trait [PDF]

, 1952
The diseases sickle cell anemia and Cooley's anemia (also known as thalassemia or Mediterranean anemia) have associated with them "minor" or "trait" forms of the disease in which the symptomatology is minimal, and the abnormalities in the red cells are ...
Rich, Alexander
core  

International forum. an investigation of iron status in blood donors [PDF]

, 2017
No abstract ...
Anderson, Nicky, Antoniewicz Papis, Jolanta, Argyrou, Isabella, Bokhorst, Arlinke, Borg Aquilina, Denise, Burta, Olivia L, Castrén, Johanna, Compernolle, Veerle, Danic, Bruno, Daugavvanaga, Anita, De Kort, Wim, Djoudi, Rachid, Faber, Jean Claude, Folléa, Gilles, Karakatsiani, Georgia, Khanirzajeva, Gulara, Liumbruno, Giancarlo M, Magnussen, Karin, Mali, Polonca, Masharova, Natalia, Mueller, Markus M, Muon, Mario, Norda, Rut, Pogłód, Ryszard, Politis, Constantina, Rosochová, Jana, Schennach, Harald, Schneider, Karin, Vaglio, Stefania, Van Den Burg, Peter, Vandewalle, Giovani, Vesga, Miguel A, Vilutyte, Edita, Vuk, Tomislav, Woimant, Geneviève, Řeháček, Vít   +35 more
core   +1 more source