Results 141 to 150 of about 2,359,639 (315)

Improved detection of blood stream pathogens by real-time PCR in severe sepsis [PDF]

, 2018
Objective: Evaluation of the technical and diagnostic feasibility of commercial multiplex real-time polymerase chain reaction (PCR) for detection of blood stream infections in a cohort of intensive care unit (ICU) patients with severe sepsis, performed ...
Bingold, Tobias, Book, Malte, Brade, Volker, Hoeft, Andreas, Hunfeld, Klaus-Peter, Lehmann, Lutz, Seifert, Harald, Steinbrucker, Martina, Stüber, Frank, Wissing, Heimo   +9 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Cost-Effectiveness Analysis of Multiplex PCR with Magnetic Resonance Detection versus Empiric or Blood Culture-Directed Therapy for Management of Suspected Candidemia [PDF]

, 2016
Brandon S. Walker, Margaret V. Powers‐Fletcher, Robert L. Schmidt, Kimberly E. Hanson   +3 more
openalex   +1 more source

Comparison between Polymerase Chain Reaction and Blood Culture for Diagnosis of Neonatal Sepsis. [PDF]

, 2023
Mohammed Hayder Hamad, Mazin Eidan Hadi, Ismael K. Ajam   +2 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma

, 2013
Philip C. Gach, Peter J. Attayek, Rebecca L. Whittlesey, Jen Jen Yeh, Nancy L. Allbritton   +4 more
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Retrospective Evaluation of Positive Blood Culture of Bacteremic Cases With Fatal Outcome

, 2020
Gamze Kalın Ünüvar, Feyza İzci Çetinkaya, Zeynep Türe, Ayşegül Ulu-Kılıç   +3 more
openalex   +2 more sources

Reduction of blood culture contamination rate by an educational intervention [PDF]

, 2006
Seada Eskira, Jacob Moran‐Gilad, Pnina Schlaeffer, Eytan Hyam, Nir Peled, Isabella Karakis, Klaris Riesenberg, Francisc Schlaeffer, Abraham Borer   +8 more
openalex   +1 more source