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Anemia and the Blood Donor [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2012
The World Health Organization recommends a collection rate of 10-20 whole blood units per 1000 inhabitants to address transfusion needs(1). However, demand for blood is ever-increasing as medicine continuous to develop(2). Donor selection is critical to blood transfusion safety and blood donor eligibility policies are designed to protect both the ...
Figueiredo, Maria Stella
openaire   +7 more sources

Neither COVID-19, nor cryopreservation, prevented allogeneic product infusion: A report from the National Marrow Donor Program

Frontiers in Immunology, 2022
BackgroundThe Coronavirus Disease 2019 (COVID-19) pandemic in early 2020 has resulted in an unprecedented level of uncertainty and challenge for the stem cell donor registries.
Nosha Farhadfar, Jeni Newman, Jennifer Novakovich, Jacklyn Barten, Eric T. Ndifon, Jason Oakes, Meghann Cody, Huy P. Pham, Jeffery J. Auletta, Jeffery J. Auletta, John P. Miller, Steven M. Devine, Heather E. Stefanski   +12 more
doaj   +1 more source

A snapshot of ABO, RH, and JK blood group systems in modern Ireland

Health Science Reports, 2021
Objectives This study aimed to capture a snapshot of the Irish population to determine if there had been any changes in the ABO and RH blood group system (BGS) distribution from previous Irish studies and to establish an Irish JK BGS frequency, providing
Anne Browne, Anthony Kinsella, Moira Keogh, Kieran Morris, Stephen Field   +4 more
doaj   +1 more source

Small volume bone marrow aspirates with high progenitor cell concentrations maximize cell therapy dose manufacture and substantially reduce donor hemoglobin loss

BMC Medicine, 2023
Background Bone marrow (BM) transplantation is a life-saving therapy for hematological diseases, and the BM harbors also highly useful (progenitor) cell types for novel cell therapies manufacture.
Jeremy Epah, Gabriele Spohn, Kathrin Preiß, Markus M. Müller, Johanna Dörr, Rainer Bauer, Shabnam Daqiq-Mirdad, Joachim Schwäble, Stefanie N. Bernas, Alexander H. Schmidt, Erhard Seifried, Richard Schäfer   +11 more
doaj   +1 more source

A Febrile Blood Donor [PDF]

Clinical Chemistry, 2010
A 4-day-old neonate born prematurely at 29 weeks gestation developed thrombocytopenia (platelet count 43 × 109/L) with associated severe pulmonary and intracranial hemorrhaging. Urgent transfusions with 10 mL/kg of packed red cells and 10 mL/kg of platelet concentrate were given. These were sourced from blood donated 2 days earlier in Singapore by a 21-
Tang, J.W., Ng, Y., Koay, E.S.C., Leow, G.H., Yap, E.S., Chan, D., Tan, L.K., Tambyah, P.A.   +7 more
openaire   +2 more sources

Worldwide survey on key indicators for public cord blood banking technologies: By the World Marrow Donor Association Cord Blood Working Group

Stem Cells Translational Medicine, 2021
The Cord Blood Working Group of the World Marrow Donor Association created a survey for cord blood banks (CBBs) aimed to identify and understand the main technical procedures currently used by public CBBs worldwide regarding cord blood units (CBUs ...
Monique Jöris, Katie Paulson, Lesa Foley, Merry Duffy, Sergio Querol, Susana Gomez, Etienne Baudoux   +6 more
doaj   +1 more source

Ferritin-guided iron supplementation in whole blood donors: optimal dosage, donor response, return and efficacy (FORTE)—a randomised controlled trial protocol

BMJ Open, 2022
Background Frequent whole blood donors have an increased risk of developing iron deficiency. Iron deficiency can have detrimental health effects when left untreated.
Katja van den Hurk, Maike G Sweegers, Dorine W Swinkels, Jan Karregat, Franke A Quee, Henriëtte H Weekamp, Vĕra M J Novotny, Hans L Zaaijer   +7 more
doaj   +1 more source

From Unit to Dose: A Machine Learning Approach for Precise Prediction of Hemoglobin and Iron Content in Individual Packed Red Blood Cell Units

Advanced Science, 2022
Transfusion of packed red blood cells (pRBCs) saves lives, but iron overload limits survival of chronically transfused patients. Quality control methods, which involve entering pRBC units and removing them from the blood supply, reveal that hemoglobin ...
Jeremy Epah, Ilay Gülec, Stefan Winter, Johanna Dörr, Christof Geisen, Eva Haecker, Dietmar Link, Matthias Schwab, Erhard Seifried, Richard Schäfer   +9 more
doaj   +1 more source

Absence of the CXCR4 antagonist EPI-X4 from pharmaceutical human serum albumin preparations

Journal of Translational Medicine, 2021
Background Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a natural antagonist of the CXC chemokine receptor 4 (CXCR4). EPI-X4 is a 16-mer peptide that is released from human serum albumin (HSA) by acidic aspartic proteases such as Cathepsin D and E ...
Andrea Gilg, Mirja Harms, Lia-Raluca Olari, Ann-Kathrin Urbanowitz, Halvard Bonig, Jan Münch   +5 more
doaj   +1 more source

Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

eLife, 2020
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with abnormal progenitor self-renewal and defective white blood cell differentiation.
Ana Filipa Domingues, Rashmi Kulkarni, George Giotopoulos, Shikha Gupta, Laura Vinnenberg, Liliana Arede, Elena Foerner, Mitra Khalili, Rita Romano Adao, Ayona Johns, Shengjiang Tan, Keti Zeka, Brian J Huntly, Sudhakaran Prabakaran, Cristina Pina   +14 more
doaj   +1 more source