Results 141 to 150 of about 3,039,068 (260)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Analysis of the most common causes of blood donor deferral in northern Jeddah: a single-center study

, 2019
Afnan K AlNouri,1 Lamees A Maghrabi,1 Samah S Hamdi,1 Shereen M Abd El-Ghany,2,3 Khalid A AlNouri4 1College of Medicine, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia; 2Department of Pediatrics, Ibn Sina National College ...
Hamdi SS, Abd El-Ghany SM, AlNouri KA, Maghrabi LA, AlNouri AK   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The neurodivergent blood donor: Fairness, discrimination, screening, and behavior. [PDF]

Transfusion
Ferguson E, O'Hagan N, Mills R, Pal M, Smith R, Davison K, Reynolds C, Claydon C, Akhtar N, Ropar D, French B, Marsh L, Masser B, Humpherys G, Brailsford SR.   +14 more
europepmc   +1 more source

A machine-learning method for biobank-scale genetic prediction of blood group antigens

A key element for successful blood transfusion is compatibility of the patient and donor red blood cell (RBC) antigens. Precise antigen matching reduces the risk for immunization and other adverse transfusion outcomes.
Hyvärinen, Kati,, Moslemi, Camous,, Olsson, Martin L.,, Pedersen, Ole B.,, Partanen, Jukka,, Haimila, Katri,, Erikstrup, Christian,, Biobank, Blood Service,, Ritari, Jarmo,, Lund University., Ostrowski, Sisse R.,, Ritari, Jarmo, Camous Moslemi, Ole B Pedersen, Erikstrup, Christian, Martin L Olsson, Katri Haimila, Partanen, Jukka, Moslemi, Camous, Christian Erikstrup, Kati Hyvärinen, Ostrowski, Sisse R., Hyvärinen, Kati, Pedersen, Ole B., Biobank, Blood Service, Blood Service Biobank, Sisse R Ostrowski, Haimila, Katri, Jarmo Ritari, Olsson, Martin L., Jukka Partanen   +30 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Blood donor serosurveys and national dengue burden estimates in Argentina. [PDF]

Lancet Reg Health Am
Bernaldo de Quirós FG, Macchia A.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Blood Donor Deferral Patterns at a Tertiary Care Hospital in Central India: A Retrospective Cross-Sectional Study. [PDF]

Cureus
Dad A, Patidar SK, Likhar KS, Gujar RK.
europepmc   +1 more source