Results 221 to 230 of about 5,328,488 (405)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The HLA landscape of Colombia: a high-resolution analysis of 11,576 blood donors. [PDF]

Front Immunol
Muñoz AL, Uricoechea D, Gómez LA, Argote-Bérdugo H, Bula J, Rueda MA, Rueda MG, Briceño I.   +7 more
europepmc   +1 more source

Decision letter: SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study

, 2022
Ivo Müeller
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Seroprevalence of Antibodies Against Legionella Species in Northeastern Australian Blood Donors, 2016 and 2023. [PDF]

J Infect Dis
Lethbridge J, Freppel W, Ho MF, Skinner EB, Rustanti L, Roulis E, Rudd PA, Faddy HM, Young MK, Herrero LJ.   +9 more
europepmc   +1 more source

Higher Percentage of Donor CD 34+ Expression in Peripheral Blood of Simultaneous Pancreas/Kidney/Donor Bone Marrow Versus Than Kidney/Islet Cell/Donor Bone Marrow Recipients

, 1998
George W. Burke, Gaetano Ciancio, Rolando García-Morales, Camillo Ricordi, Rodolfo Alejandro, David Roth, Andreas G. Tzakis, J. Miller   +7 more
openalex   +1 more source

ENHANCING DONOR RETENTION: A COMPREHENSIVE META-ANALYSIS OF INTERVENTIONS FOR FIRST-TIME BLOOD DONORS

, 2023
PGLB Borges, J. L. Ganem, ALM Brito, JPR Oliveira, MEDDSPE Silva, JVFA Cordeiro, ICR Diogo, JPMRJ Silva   +7 more
openalex   +1 more source

Blood donations: justifying blood donor restrictions [PDF]

British Journal of Haematology, 2015
John N. Spence, Fahad M. Iqbal
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source