Results 211 to 220 of about 10,661,666 (408)

Homogenisation of nonlinear blood flow in periodic networks: the limit of small haematocrit heterogeneity [PDF]

arXiv
In this work we develop a homogenisation methodology to upscale mathematical descriptions of microcirculatory blood flow from the microscale (where individual vessels are resolved) to the macroscopic (or tissue) scale. Due to the assumed two-phase nature of blood and specific features of red blood cells (RBCs), mathematical models for blood flow in the
arxiv  

Capillary pericytes regulate cerebral blood flow in health and disease

Nature, 2014
C. Hall, C. Reynell, Bodil Gesslein, N. Hamilton, Anusha Mishra, B. Sutherland, F. O'Farrell, A. Buchan, M. Lauritzen, D. Attwell   +9 more
semanticscholar   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

HeartSmart® for routine optimization of blood flow and facilitation of early goal-directed therapy

Open Access Journal of Clinical Trials, 2010
Kenneth Warring-Davies1, Martin Bland21The Intensive Care Unit, Bradford Royal Infirmary, Bradford, West Yorkshire, UK; 2Department of Health Sciences, University of York, York, North Yorkshire, UKAbstract: The empirical physiological formulae of the new
Kenneth Warring-Davies, Martin Bland
doaj  

A STUDY OF BLOOD FLOW IN MINUTE VESSELS OF THE PANCREATIC REGION OF THE RAT WITH REFERENCE TO INTERMITTENT CORPUSCULAR FLOW IN INDIVIDUAL CAPILLARIES [PDF]

, 1959
A.A. Palmer
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Spatio-Temporal Instabilities of Blood Flow in a Model Capillary Network [PDF]

arXiv
We present experimental evidence of multiple blood flow configurations in a relatively simple microfluidic network under constant inlet conditions. We provide evidence of multistability and unsteady dynamics and find good agreement with a theoretical {one-dimensional advection} model for blood flow in microvascular networks{ that relies on the widely ...
arxiv  

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

FEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei, Amir Barzegar Behrooz, Marco Cordani, Mahmoud Aghaei, Negar Azarpira, Daniel J. Klionsky, Saeid Ghavami   +6 more
wiley   +1 more source

VASCULAR CHANGES AFTER INTERFERENCE WITH THE BLOOD FLOW OF THE FEMORAL HEAD OF THE RABBIT [PDF]

, 1957
André Lemoine
openalex   +1 more source