Results 61 to 70 of about 318,892 (304)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

A Deep Neural Network Method for Arterial Blood Flow Profile Reconstruction

Entropy, 2021
Arterial stenosis will reduce the blood flow to various organs or tissues, causing cardiovascular diseases. Although there are mature diagnostic techniques in clinical practice, they are not suitable for early cardiovascular disease prediction and ...
Dan Yang, Yuchen Wang, Bin Xu, Xu Wang, Yanjun Liu, Tonglei Cheng   +5 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Evaluation of renal function in dogs using pulsed Doppler ultrasonography

Open Veterinary Journal
Background: In human medicine, efforts have been made to evaluate venous blood flow in the kidneys to diagnose renal disease and estimate renal function.
Takami Ito, Kiwamu Hanazono, Kenjirou Miyoshi, Daiji Endoh   +3 more
doaj   +1 more source

Determining arterial blood velocity using MAUI software from recorded doppler ultrasound videos [PDF]

, 2017
Objectives: The purpose of this study was to investigate the repeatability and reproducibility of a new software, developed to provide measurements of arterial blood velocity from recorded Doppler ultrasound videos.
Deglint, Jason, Egana, Mikel, Gawish, Ahmed, Hughson, Richard, Rocha, Joel, Wong, Alex, Zuj, Kathryn   +6 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

A simple deep breathing test reveals altered cerebral autoregulation in type 2 diabetic patients [PDF]

, 2018
Aims/hypothesis: Patients with diabetes mellitus have an increased risk of stroke and other cerebrovascular complications. The purpose of this study was to evaluate the autoregulation of cerebral blood flow in diabetic patients using a simple method that
Brown, C., Hilz, M., Marthol, H., Ziegler, D., Zikeli, U.   +4 more
core  

Differences in Ocular Blood Flow Between People of African and European Descent With Healthy Eyes [PDF]

, 2016
Purpose: To investigate differences in ocular blood flow between people of African descent (AD) and European descent (ED) with healthy eyes. Materials and Methods: Retrobulbar and retinal capillary blood flow was assessed in 1 eye of 58 participants ...
Eikenberry, Jennifer, Harris, Alon, Kaskan, Betül, Olinde, Carine, Racette, Lyne, Ramezani, Koosha, Siesky, Brent, Tobe, Leslie A., WuDunn, Darrell   +8 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

NUMERICAL ANALYSIS IN ARTERIAL STENOSIS AFFECTED BY ISCHEMIC HEART DISEASE USING FINITE VOLUME METHOD

Barekeng
Atherosclerosis is the narrowing of blood vessels caused by the buildup of cholesterol plaque on the walls of the arteries. Excessive buildup of cholesterol plaque disrupts the circulatory system, thereby affecting the speed and pressure of blood flow ...
Arif Fatahillah, Alfiani Dyah Pratiwi, Susi Setiawani, Arika Indah Kristiana, Robiatul Adawiyah   +4 more
doaj   +1 more source