Results 161 to 170 of about 39,011 (251)

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Externally validated risk prediction models for gestational diabetes mellitus: A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
A systematic review of 33 gestational diabetes risk prediction models found fair discrimination but significant methodological weaknesses. With 69% of studies at high risk of bias, future research must adopt rigorous, scalable validation strategies to enhance clinical utility.
Beminate Lemma Seifu, Yitayeh Belsti, Nigus Bililign Yimer, Rebecca F. Goldstein, Joanne Enticott, Helena Teede   +5 more
wiley   +1 more source

Pubertal Timing Associates With Cardiometabolic Markers During Puberty and in Young Adulthood

Acta Paediatrica, EarlyView.
ABSTRACT Aim To study how pubertal timing associates with cardiometabolic measures in puberty and young adulthood. Methods Cardiovascular risk factors, anthropometry and pubertal development were regularly studied in STRIP study subjects until age 26 years.
Saga Nummela, Katja Pahkala, Sinikka Karppinen, Jorma Toppari, Olli Raitakari, Jorma Viikari, Tapani Rönnemaa, Harri Niinikoski   +7 more
wiley   +1 more source

Metabolic Risk Factors Are Associated With Weight Status Change Over Four Years in Children Aged 4–6 Years With Obesity

Acta Paediatrica, EarlyView.
ABSTRACT Aim It is unclear how early childhood obesity treatment affects metabolic risk. This study assessed long‐term metabolic health in children with obesity aged 4–6 years and examined associations with weight status. Methods This prospective cohort study pooled data from the Sweden‐based More and Less randomized controlled trial, which compared a ...
Markus Brissman, Anna Ek, Stella Wennborg, Karin Nordin, Karin Eli, Annika Janson, Paulina Nowicka   +6 more
wiley   +1 more source

Hyperglycaemia as a predictor of morbidity and mortality in patients receiving an allogeneic haematopoietic stem cell transplantation

British Journal of Haematology, EarlyView.
Summary Allogeneic haematopoietic stem cell transplantation (allo‐HSCT) is an effective treatment for patients with haematological malignancies; however, post‐transplant complications, including infections and acute graft‐versus‐host disease (aGvHD), remain significant issues. Identifying modifiable risk factors is therefore critical to improve patient
Marieke Tienstra, Fleur R. Goemans, Kylie Keijzer, Inge V. G. Oteman, Carin L. E. Hazenberg, Jaap A. van Doesum, Anne G. H. Niezink, Goda Choi, Gerwin A. Huls, Peter R. van Dijk, Hilde A. M. Kooistra, Tom van Meerten, Linde M. Morsink   +12 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Transcriptomic and metabolomic analyses reveal that lobeglitazone ameliorates hepatic steatosis in rats concurrent with regulation of mitochondrial pyruvate metabolism

British Journal of Pharmacology, EarlyView.
Background and Purpose Lobeglitazone is a thiazolidinedione and PPARγ agonist that improves metabolic parameters and hepatic steatosis, but its mechanisms are not fully understood. This study investigated the effects of lobeglitazone on hepatic transcriptomic and metabolic profiles in a rat model of obesity and Type 2 diabetes mellitus.
Hyekyung Yang, Su Young Son, Youngmi Song, Hyewon Choi, In‐Gu Do, Choong Hwan Lee, Cheol‐Young Park   +6 more
wiley   +1 more source

Brazilian multicenter study for the evaluation of patients' satisfaction of blood glucose self-monitoring with BGStar(®) blood glucose meter in insulinized patients with diabetes mellitus type 1 and 2. [PDF]

Diabetol Metab Syndr, 2016
Hissa MN.
europepmc   +1 more source

Input Visualizations to Track Health Data by Older Adults with Multiple Chronic Conditions

Computer Graphics Forum, EarlyView.
Abstract Older adults living with multiple chronic conditions (MCC) can considerably benefit from collecting and reflecting on their health data. Many older adults collect their health data using various approaches, such as digital tools or handwritten notebooks.
Shri Harini Ramesh, Foroozan Daneshzand, Matteo Sotelo, Mahsa Sinaei, Fateme Rajabiyazdi   +4 more
wiley   +1 more source