Results 31 to 40 of about 688 (113)

Successful Desensitization with Imlifidase and Daratumumab in a Highly Immunized, Crossmatch Positive, Blood Group-Incompatible Living-Donor Re-Transplant Recipient with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Transfusion Medicine and Hemotherapy
<b><i>Introduction:</i></b> The transplantation of highly sensitized patients remains a major obstacle. Immunized patients wait longer for a transplant if not prioritized, and if transplanted, their transplant outcome is worse.
Schrezenmeier, Eva, Choi, Mira, Globke, Brigitta, Dörner, Thomas, Leimbach, Alexandra, Osmanodja, Bilgin, Schramm, Alexander, Amann, Kerstin, Eckardt, Kai-Uwe, Budde, Klemens, Öllinger, Robert, Lachmann, Nils, Halleck, Fabian   +12 more
openaire   +3 more sources

Development and validation of a pediatric transfusion medicine education assessment tool

Transfusion, Volume 66, Issue 1, Page 205-217, January 2026.
Abstract Background Pediatric transfusion medicine presents unique challenges due to differences in pediatric physiology and pathology compared to adults. Research shows that pediatric healthcare professionals have knowledge gaps in transfusion medicine, contributing to suboptimal practice.
Ines Zuna, Yulia Lin, Richard Haspel, Catharine M. Walsh, Jeffrey N. Bone, Casey Kapitany, Lani Lieberman, Teresa Skelton   +7 more
wiley   +1 more source

Suppression of RBC alloimmunization and regulation of CD4+T cell dependence by C3 is not due to genetic confounders in mice

Transfusion, Volume 66, Issue 1, Page 178-186, January 2026.
Abstract Background Activation of complement protein C3 generally enhances antibody responses and C3‐null mice have decreased antibody‐based immunity. Mener et al. have reported a paradoxical suppressor function for C3 in alloimmunization to transfused RBCs as alloantibodies are increased in C3‐null mice.
Arijita Jash, Ariel Hay, James C. Zimring   +2 more
wiley   +1 more source

Variability of blood parameters across ABO and Rh blood groups: Insights from a master health check-up data of adult population [PDF]

Medical Laboratory Journal
Background: The ABO and Rh blood group systems have been associated with variations in disease susceptibility. This study aimed to assess the variability in blood parameters, including red cell parameters and metabolic parameters (Renal function, hepatic
Joseph KI, Mohan Kumar, Kanagasabapathy Sivagami, Jeevithan Shanmugam, Periasamy Aparnavi   +4 more
doaj  

Effectiveness of antenatal intravenous immunoglobulin treatment in recurrent fetal and neonatal alloimmune thrombocytopenia

Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 6, Page 773-780, December 2025.
ABSTRACT Objective To evaluate the effectiveness of antenatal intravenous immunoglobulin (IVIG) treatment for recurrent fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to determine factors associated with a good response to treatment. Methods This was a retrospective cohort study of pregnant women diagnosed with FNAIT and managed at a single
K. Zloto, S. Cohen, L. Batsry, A. Schwartz, T. Weissbach, H. Avnet, B. Weisz, Y. Yinon   +7 more
wiley   +1 more source

Guidelines from the expert advisory committee on the Safety of Blood, Tissues and Organs (SaBTO) on patient consent and shared decision‐making for blood transfusion

British Journal of Haematology, Volume 207, Issue 6, Page 2314-2321, December 2025.
The key points to be discussed with a patient when obtaining consent to transfusion are the reason for the transfusion, the benefits and risks of transfusion, the possible alternatives to transfusion, the process for transfusion, any specific transfusion requirements that the patient may have, the consequences of refusing transfusion and the ability to
Michael F. Murphy, Damien Carson, Anwen Davies, Stephanie Ditcham, Graham Donald, Roger Graham, Lizzie Hutchinson, Paul Kerr, Denise McKeown, John Moppett, Shruthi Narayan, Paolo Polzella, Ella Poppitt, Megan Rowley, Tracey Shackleton, Julie Staves, James Neuberger   +16 more
wiley   +1 more source

Drone‐Assisted Organ Transport: A Scoping Review of Clinical, Regulatory, and System Readiness

Clinical Transplantation, Volume 39, Issue 12, December 2025.
ABSTRACT Organ transport remains a critical determinant of transplant success, with delays during transfer prolonging cold ischemia time (CIT) and increasing the risk of delayed graft function or organ discard. Uncrewed aerial vehicles (UAVs) have emerged as a potential means to enhance the speed, predictability, and resilience of transplant logistics.
Robson G. Gilmour, Mekhola Hoff
wiley   +1 more source

A Prospective Pilot Study to Investigate Whether Donor‐Derived Cell‐Free DNA Can Be Used as a Biomarker of Recurrent IgA Nephropathy Post–Kidney Transplantation

International Journal of Immunogenetics, Volume 52, Issue 6, Page 342-351, December 2025.
ABSTRACT IgA nephropathy (IgAN) is one of the most prevalent glomerulonephropathies and commonly leads to kidney failure. The recurrence of IgAN following transplantation remains a significant concern. Currently, detecting IgAN recurrence requires a kidney biopsy, highlighting the need for non‐invasive biomarkers such as donor‐derived cell‐free DNA (dd‐
Judith Owusuwaah Asiedu‐Basoah, Stephen Weston, Jonathan Barratt, Justyna Szklarzewicz, Paul Dunn   +4 more
wiley   +1 more source

The Impact of Complement Factor H‐Related Protein Gene Deletions on Kidney Transplantation

Scandinavian Journal of Immunology, Volume 102, Issue 6, December 2025.
In this study, we found that rs7542235 allele G tags a deletion of the CFHR1 gene. We also found that rs6677604 allele A tags a deletion of the whole CFHR3–1 locus. The plasma proteomics studies show that both variants are associated with an altered expression of FH/FHR proteins thus revealing a novel level of intricate regulation of the complement ...
Salla Markkinen, A. Inkeri Lokki, Ilkka Helanterä, Jarmo Ritari, Jukka Partanen, Seppo Meri, Kati Hyvärinen   +6 more
wiley   +1 more source

Biological Effects of F(ab′)2 Fragments Generated by Imlifidase From Anti‐HLA IgG Antibodies From Transplant Patients

HLA, Volume 106, Issue 6, December 2025.
ABSTRACT Imlifidase cleaves intact IgG molecules, generating F(ab′)2 fragments that still bind to the target antigen but are devoid of the Fc‐dependent effector functions, notably complement activation. Imlifidase (Idefirix) has been conditionally approved for desensitisation to enable kidney transplantation in highly sensitised adult patients.
Magali Devriese, Ilaria Carelli, Lisa Giraldo, Alexis Pin, Noé Groshaeny, Sephora Da Silva, Robert Bockermann, Jean‐Luc Taupin   +7 more
wiley   +1 more source