Results 41 to 50 of about 1,911,098 (267)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tranexamic acid versus hot saline irrigations in endoscopic sinus surgery: a review and meta-analysis

Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
Objectives: Intraoperative bleeding may compromise the results of functional endoscopic sinus surgery (FESS). Tranexamic acid (TXA) and hot saline irrigations (HSI) are potentially useful in reducing blood loss during FESS.
Francisco Alves de Sousa, Mariline Santos, Paula Branco, Joana Ida Dias, Sara Costa, Ana Nóbrega Pinto, Luís Meireles, Miguel Gonçalves Ferreira   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Do Patients with Borderline Anemia Need Treatment before Total Hip Arthroplasty? A Propensity Score‐Matched Cohort Study

Orthopaedic Surgery
Objective Preoperative anemia has been identified as a modifiable risk factor for multiple adverse outcomes. In real clinical practice, considering treatment of anemia would increase costs and delay surgery.
Lijun Cai, Liyile Chen, Chengcheng Zhao, Guangtao Han, Qiuru Wang, Pengde Kang   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Predicting intraoperative major blood loss in microsurgery for brain arteriovenous malformations

Frontiers in Medicine
ObjectiveIntraoperative blood loss poses a great challenge for brain arteriovenous malformation (AVM) microsurgery, although systematic researches are still lacking. This study aimed to identify factors predicting intraoperative major blood loss in brain
Jichun Shi, Shuangxiang Xu, Yu Feng, Wei Wei, Yichun Zou, Wenping Xiong, Wenyuan Zhao, Tingbao Zhang, Hao Peng, Hao Peng, Jincao Chen   +10 more
doaj   +1 more source

Single intravenous bolus versus perioperative continuous infusion of tranexamic acid to reduce blood loss in abdominal oncosurgical procedures: A prospective randomized double-blind clinical study

Journal of Anaesthesiology Clinical Pharmacology, 2018
Background and Aims: Intraoperative use of a single bolus dose of tranexamic acid may not be sufficient to prevent bleeding in the early postoperative period. The present study was carried out to compare the effect of two dose regimens of tranexamic acid
Ramakrishna Prasad, Abhiruchi Patki, Shibany Padhy, Gopinath Ramchandran   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bridging to orthotopic heart transplant: Reducing the risk of intra-operative blood loss

JHLT Open
Background: Orthotopic heart transplantation remains the gold standard for patients with end-stage heart failure. Many devices exist to bridge patients with heart failure to transplant.
Phoebe Miller, MS MD, Andrew Akcelik, MD, Alyssa Murillo, MD, Alison Baskin, MD, Alexander Merriman, PhD, Mohammad Arammash, BS, Shreyas Kiran, BS, Jason Smith, MD, Amy G. Fiedler, MD   +8 more
doaj   +1 more source