Results 61 to 70 of about 3,547,549 (313)

The “Hypertension Approaches in the Elderly: a Lifestyle study” multicenter, randomized trial (HAEL Study): rationale and methodological protocol [PDF]

, 2019
Background: Hypertension is a clinical condition highly prevalent in the elderly, imposing great risks to cardiovascular diseases and loss of quality of life.
Alberton, Cristine Lima, Alves, Leonardo, Bock, Patrícia Martins, Botton, Cíntia Ehlers, Brizio, Maria Laura, Campelo, Paula, da Silveira, Anderson Donelli, De Nardi, Angélica Trevisan, Domingues, Marlos Rodrigues, Ferreira, Gustavo Dias, Galliano, Leony, Helal, Lucas, Mendes, Graciele Ferreira, Moraes, Ruy Silveira, Pescatello, Linda S., Pfeifer, Lucinéia Orsolin, Pinto, Stephanie Santana, Polanczyk, Carisi Anne, Santos, Lucas Porto, Schaan, Beatriz D., Schaun, Gustavo Zaccaria, Tanaka, Hirofumi, Umpierre, Daniel, Wilhelm, Eurico N.   +23 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tourniquet application in primary total knee arthroplasty for osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

Frontiers in Surgery, 2023
ObjectiveThe aim of this study was to identify the influence of a tourniquet on the blood loss, transfusion requirement, swelling, pain, knee function, range of motion (ROM), operation time, bone cement mantle thickness, and complications in patients ...
Jinchang Han, Jinchang Han, Xiao-yu Zhang, Xiao-yu Zhang, Shi-yin Mu, Shi-long Liu, Shi-long Liu, Qing-tong Cui, Qing-tong Cui, Chao Zhang, Chao Zhang, Ai-feng Liu, Ai-feng Liu   +12 more
doaj   +1 more source

Force balance and membrane shedding at the Red Blood Cell surface

, 2006
During the aging of the red-blood cell, or under conditions of extreme echinocytosis, membrane is shed from the cell plasma membrane in the form of nano-vesicles.
D. E. Discher, J. M. Werre, L. Backman, N. G. Van Kampen, Nir Gov, Pierre Sens, R. Bucki, R. E. Waugh, S. Levin, S.-C. Liu, S. P. Sutera, V. Bennett, W. H. Reinhart, Z. Tochner   +13 more
core   +1 more source

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes [PDF]

, 2008
Factor V Leiden (FVL) and ABO(H) blood groups are the common influences on haemostasis and retrospective studies have linked FVL with pregnancy complications. However, only one sizeable prospective examination has taken place.
Carstairs V., Cashner K., Catalano P., Clark P., Escuriola Ettingshausen C., Gill A., Harlap S., Lindqvist P., Lindqvist P.G., May D., Morris R., Neerhof M., Preston A., Robert A., Samueloff A., Sezik M., South J., van ‘t Veer C.   +17 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tranexamic acid versus hot saline irrigations in endoscopic sinus surgery: a review and meta-analysis

Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
Objectives: Intraoperative bleeding may compromise the results of functional endoscopic sinus surgery (FESS). Tranexamic acid (TXA) and hot saline irrigations (HSI) are potentially useful in reducing blood loss during FESS.
Francisco Alves de Sousa, Mariline Santos, Paula Branco, Joana Ida Dias, Sara Costa, Ana Nóbrega Pinto, Luís Meireles, Miguel Gonçalves Ferreira   +7 more
doaj   +1 more source