Results 71 to 80 of about 6,539,020 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dietary Protein and Blood Pressure: A Systematic Review [PDF]

, 2010
Background - Elevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide. Recently, interest has grown in the role of dietary protein in human BP.
Wieke Altorf-van der Kuil, Bakker, S.J.L., Bakker, Stephan J. L., Navis, G., Johanna M Geleijnse, Geleijnse, J.M., Baak, M.A. van, Geleijnse Johanna M., Kuil, W.A. van der, Bakker Stephan J. L., van't Veer, Pieter, Bakker, Stephan J. L.; id_orcid, Marleen A van Baak, Geleijnse, Johanna M., Mariëlle F Engberink, van Baak, M.A., Mariëlle F. Engberink, Engberink, Marielle F., Stephan J L Bakker, Altorf-van der Kuil, Wieke, van Baak Marleen A., Pieter van 't Veer, Brink, Elizabeth J., Wieke Altorf – van der Kuil, Bakker, S.J., van Baak, Marleen A., Johanna M. Geleijnse, Brink Elizabeth J., Veer, P., van 't, Engberink Mariëlle F., Brink, E.J., van 't Veer Pieter, Veer, P. van't, Gerjan Navis, van 't Veer, P., Marleen A. van Baak, Navis, Gerjan, Elizabeth J. Brink, Engberink, M.F., Stephan J. L. Bakker, van der Kuil, W., Navis Gerjan, Altorf-van der Kuil, W., Baak, M.A., van, Elizabeth J Brink, Altorf, W., Altorf – van der Kuil Wieke   +46 more
core   +3 more sources

Do Patients with Borderline Anemia Need Treatment before Total Hip Arthroplasty? A Propensity Score‐Matched Cohort Study

Orthopaedic Surgery
Objective Preoperative anemia has been identified as a modifiable risk factor for multiple adverse outcomes. In real clinical practice, considering treatment of anemia would increase costs and delay surgery.
Lijun Cai, Liyile Chen, Chengcheng Zhao, Guangtao Han, Qiuru Wang, Pengde Kang   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Predicting intraoperative major blood loss in microsurgery for brain arteriovenous malformations

Frontiers in Medicine
ObjectiveIntraoperative blood loss poses a great challenge for brain arteriovenous malformation (AVM) microsurgery, although systematic researches are still lacking. This study aimed to identify factors predicting intraoperative major blood loss in brain
Jichun Shi, Shuangxiang Xu, Yu Feng, Wei Wei, Yichun Zou, Wenping Xiong, Wenyuan Zhao, Tingbao Zhang, Hao Peng, Hao Peng, Jincao Chen   +10 more
doaj   +1 more source

Single intravenous bolus versus perioperative continuous infusion of tranexamic acid to reduce blood loss in abdominal oncosurgical procedures: A prospective randomized double-blind clinical study

Journal of Anaesthesiology Clinical Pharmacology, 2018
Background and Aims: Intraoperative use of a single bolus dose of tranexamic acid may not be sufficient to prevent bleeding in the early postoperative period. The present study was carried out to compare the effect of two dose regimens of tranexamic acid
Ramakrishna Prasad, Abhiruchi Patki, Shibany Padhy, Gopinath Ramchandran   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bridging to orthotopic heart transplant: Reducing the risk of intra-operative blood loss

JHLT Open
Background: Orthotopic heart transplantation remains the gold standard for patients with end-stage heart failure. Many devices exist to bridge patients with heart failure to transplant.
Phoebe Miller, MS MD, Andrew Akcelik, MD, Alyssa Murillo, MD, Alison Baskin, MD, Alexander Merriman, PhD, Mohammad Arammash, BS, Shreyas Kiran, BS, Jason Smith, MD, Amy G. Fiedler, MD   +8 more
doaj   +1 more source

Assessment of Accuracy of Continuous Noninvasive versus Invasive Method of Hemoglobin Estimation in Patients Undergoing Pituitary Surgery

Journal of Neuroanaesthesiology and Critical Care, 2018
Aim Determination of hemoglobin (Hb) concentration by standard methods is time consuming, invasive, and intermittent. Noninvasive (NI) methods of Hb estimation are less time consuming, and reduce the risk of infection, number of required working ...
Indu Kapoor, Charu Mahajan, Ruhi Mamuliya, Hemanshu Prabhakar   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source