Results 71 to 80 of about 1,660,529 (290)
Molecular Oncology, EarlyView.Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
National Journal of Medical Research, 2020 Introduction: Head and Neck cancer surgical operations are often associated with major blood loss requiring substitution, usually by homologous blood transfusion. The goal of this study is to retrospectively examine the intraoperative blood loss for the
Sandeep Ghosh +5 more
doaj
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Philippine Journal of OrthopaedicsObjectives. Pertrochanteric fractures, commonly incurred by the elderly from low-energy falls, require surgical management. Visible blood loss in the perioperative period is inconsistent with the big drop in hemoglobin seen postoperatively.
Martha Camille Dollete +3 more
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Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Estimation of Blood Loss in Total Knee Arthroplasty with or Without Tourniquet
Pakistan Journal of Medical Research, 2020 Background: Total knee arthroplasty (TKA) is a procedure performed for end stage knee osteoarthritis to reinstate leg function, pain control and improve quality of life. The surgery, however, is associated with a substantial risk of concealed blood loss
Mansoor Ali Khan +3 more
doaj
CLINICAL STUDIES OF THE BLOOD VOLUME. VIII. MACROCYTIC AND HYPOCHROMIC ANEMIAS DUE TO CHRONIC BLOOD LOSS, HEMOLYSIS AND MISCELLANEOUS CAUSES, AND POLYCYTHEMIA VERA 1 [PDF]
, 1939 John G. Gibson +2 more
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