Results 51 to 60 of about 4,927,683 (288)

Blood/plasma secretome and microvesicles

, 2013
A major but hitherto overseen component of the blood/plasma secretome is that of extracellular vesicles (EVs) which are shed from all blood cell types. These EVs are made up of microvesicles (MVs) and exosomes.
Lange, S., Kosgodage, U., Azam, S., Stratton, D., Inal, J.M., Antwi-Baffour, S.   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cold atmospheric plasma ameliorating skin barrier in chronic kidney disease

npj Regenerative Medicine
Chronic kidney disease (CKD)-associated skin complications, including pruritus and xerosis, remain clinically challenging due to poorly understood pathological mechanisms.
Meng Wang, Hongli Jiang, Dingxin Liu, Wuying Xu, Lei Chen, Zifeng Wang, Hua Liu, Xue Zhao, Siyue Zhai   +8 more
doaj   +1 more source

Brain Tumor-Induced Changes in Routine Parameters of the Lipid Spectrum of Blood Plasma and Its Short-Chain Fatty Acids

Current Issues in Molecular Biology
The aim of this research was to provide a comparative analysis of the major parameters of the blood lipid spectrum found both in the case of brain tumors and in atherosclerosis, as well as to assess the correlation of these indicators with the ...
Larisa Obukhova, Natalia Shchelchkova, Igor Medyanik, Konstantin Yashin, Artem Grishin, Oksana Bezvuglyak, Ilkhom Abdullaev   +6 more
doaj   +1 more source

The effects of size and period of administration of gold nanoparticles on rheological parameters of blood plasma of rats over a wide range of shear rates: In vivo

Lipids in Health and Disease, 2011
Background Blood viscosity appears to be independent predictor of stroke, carotid intima-media thickening, atherosclerosis and most cardiovascular diseases.
Abdelhalim Mohamed Anwar K
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Creation of a plasma collection for the search of diagnostic biomarkers of glial tumors

Кардиоваскулярная терапия и профилактика
Aim. To create a collection of plasma samples of patients with brain tumors (BTs) for the development of a diagnostic microRNA (ribonucleic acid) panel of glial tumors.Material and methods.
E. P. Omelchuk, N. N. Timoshkina, D. Yu. Gvaldin, N. A. Petrusenko, E. E. Rostorguev, I. A. Novikova, O. I. Kit   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Development and Validation of an HPLC-MS/MS Method for the Quantitative Determination of Etmaben in Human Blood Plasma

Разработка и регистрация лекарственных средств
Introduction. Etmaben is a promising drug for the treatment of cardiovascular diseases, widely studied in preclinical studies. In order to conduct phase I clinical trials, it is necessary to develop a bioanalytical method for the quantitative ...
P. K. Karnakova, T. N. Komarov, O. A. Archakova, D. Yu. Ivkin, E. S. Vetrova, I. I. Terninko, I. E. Shohin, I. A. Narkevich   +7 more
doaj   +1 more source