Results 171 to 180 of about 3,594,892 (285)

Real-world romiplostim dosing, response and home administration in paediatric immune thrombocytopenia. [PDF]

Br J Haematol
Harris EM, Montcrieff C, Grace RF.
europepmc   +1 more source

[Blood platelet disorders].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1993
openaire   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Pregnancy outcomes among women with inherited bleeding disorders: A matched case-control study. [PDF]

SAGE Open Med
Mansouri Z, Ashtari S, Ghaemi M, Hantoushzadeh S, Haghollahi F, Shariat M, Mehrabi MM, Shirdel S, Toogeh S, Toogeh G, Akbari R.   +10 more
europepmc   +1 more source

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, Accepted Article.
Objectives VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

The Association Between Peripheral Complete Blood Count Parameters and Depressive Symptoms: A Cross-Sectional Study in Eastern Sudan. [PDF]

J Clin Med
Alharthi SS, Omar SM, Alharbi HY, Alwabili AA, Adam I.   +4 more
europepmc   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Late Vitamin K Deficiency Bleeding Presenting as Subacute Subdural Hemorrhage in an Exclusively Breastfed Infant: A Preventable Life-Threatening Condition-A Case Report. [PDF]

Clin Case Rep
Ali YK, Ali MN, Ahmed FH, Ahmed FA, Ismail FA, Hirsi IM, Ahmed SA, Mohamed MM.   +7 more
europepmc   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Eltrombopag use in surgical procedures in inherited thrombocytopenia: expanding the role of thrombopoietin-receptor agonists. [PDF]

Res Pract Thromb Haemost
Oliveira M, Coutinho M, Cruz E, Morais S.   +3 more
europepmc   +1 more source