, 2017 Von Willebrand Disease (VWD) is a blood clotting disorder characterized by low levels of the Von Willebrand Factor (VWF) in the blood. VWF is functions to bind platelets and promote clotting of the blood when vascular injury occurs.
Misla David, Ramon
core +2 more sources
Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
Marine Drugs, 2011 The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects.
Suzi Meneses Ribeiro +6 more
doaj +1 more source
Transport of platelets induced by red blood cells based on mixture theory [PDF]
arXiv, 2017 Thrombosis is a common complication following the surgical implantation of blood contacting devices, and is strongly influenced by the phenomenon of near-wall enrichment of platelets. This paper describes a multi-constituent continuum approach to study this phenomenon.
arxiv
A Mathematical Model of Platelet Aggregation in an Extravascular Injury Under Flow [PDF]
arXiv, 2020 We present the first mathematical model of flow-mediated primary hemostasis in an extravascular injury, which can track the process from initial deposition to occlusion. The model consists of a system of ordinary differential equations (ODE) that describe platelet aggregation (adhesion and cohesion), soluble-agonist-dependent platelet activation, and ...
arxiv
Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]
, 2015 BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G +4 more
core +1 more source
Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells. [PDF]
, 2018 Platelet-activating factor (PAF) is a potent phospholipid mediator that exerts various pathophysiological effects by interacting with a G protein-coupled receptor.
Abood, Mary E. +4 more
core +1 more source
Optimization of human mesenchymal stem cell manufacturing: the effects of animal/xeno-free media. [PDF]
, 2015 Due to their immunosuppressive properties, mesenchymal stem cells (MSC) have been evaluated for the treatment of immunological diseases. However, the animal-derived growth supplements utilized for MSC manufacturing may lead to clinical complications ...
Hommes, Daniel W +6 more
core +3 more sources
Resolving the missing link between single platelet force and clot contractile force
iScience, 2022 Summary: Blood clot contraction plays an important role in wound healing and hemostasis. Although clot contraction is known to be driven by platelets, how single platelet forces relate to the forces generated by macroscopic clots remains largely unknown.
Yueyi Sun +4 more
doaj
Physical activity intervention for elderly patients with reduced physical performance after acute coronary syndrome (HULK study): Rationale and design of a randomized clinical trial [PDF]
, 2018 Background: Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) and they represent independent risk factors for disability, morbidity, hospital readmission and mortality.
Biscaglia, Simone +19 more
core +2 more sources
Synergistic effect of shear and ADP on platelet growth on ZTA and Ti6Al4V surfaces [PDF]
arXiv, 2020 Continuous-flow ventricular assist devices (VADs) have been an increasingly common, life-saving therapy for advanced heart-failure patients, but elevate the risk of thrombosis due to a combination of non-physiological hemodynamics and synthetic biomaterials.
arxiv