Results 81 to 90 of about 10,778,146 (402)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Pengaruh Teknik Relaksasi Otot Progresif Terhadap Tingkat Kecemasan Dan Penurunan Tekanan Darah Pada Pasien Hipertensi Di Rumah Sakit Islam Siti Khadijah Palembang [PDF]

, 2017
Background: According to WHO 2012 there are 839 million cases of hypertension, patients with hypertension more experienced by women (30%) and men (29%). Hypertension is an increase in blood pressure exceeding 160/95 mmHg.
Erviana, Nia
core  

Variations in Arterial Blood Pressure after Kidney Transplantation [PDF]

, 1973
The course of hypertension within the first 2 months after kidney transplantation was correlated with renal function, plasma renin activity (PRA), and the daily maintenance dose of prednisone in 18 homograft recipients.
CORMAN, JACQUES L, HALGRIMSON, CHARLES G, KATZ, FRED H, LANOIS, BERNARD, PINNGGERA, WULF, POPOVTZER, MORDECAI M, ROBINETTE, JOHN, STARZL, THOMAS E   +7 more
core   +1 more source

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Nature Genetics, 2018
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis.
Ayush Giri, J. Hellwege, Jacob M. Keaton, Jihwan Park, Chengxiang Qiu, H. Warren, E. Torstenson, C. Kovesdy, Yan V. Sun, O. Wilson, C. Robinson-Cohen, C. Roumie, C. Chung, K. Birdwell, S. Damrauer, S. Duvall, D. Klarin, Kelly Cho, Yu Wang, E. Evangelou, C. Cabrera, L. Wain, Rojesh Shrestha, Brian S. Mautz, Elvis Akwo, M. Sargurupremraj, S. Debette, M. Boehnke, L. Scott, J. Luan, Jinghua Zhao, Sara M. Willems, S. Thériault, Nabi Shah, C. Oldmeadow, P. Almgren, R. Li-Gao, N. Verweij, Thibaud S. Boutin, M. Mangino, I. Ntalla, E. Feofanova, P. Surendran, J. Cook, Savita Karthikeyan, N. Lahrouchi, Chunyu Liu, N. Sepúlveda, T. Richardson, A. Kraja, P. Amouyel, M. Farrall, N. Poulter, M. Laakso, E. Zeggini, P. Sever, R. Scott, C. Langenberg, N. Wareham, D. Conen, C. Palmer, J. Attia, D. Chasman, P. Ridker, O. Melander, D. Mook-Kanamori, P. Harst, F. Cucca, D. Schlessinger, C. Hayward, T. Spector, M. Jarvelin, B. Hennig, N. Timpson, Wei-Qi Wei, Joshua C. Smith, Yaomin Xu, M. Matheny, E. Siew, C. Lindgren, K. Herzig, G. Dedoussis, J. Denny, B. Psaty, J. Howson, P. Munroe, C. Newton‐Cheh, M. Caulfield, P. Elliott, J. Gaziano, J. Concato, P. Wilson, P. Tsao, D. V. Velez Edwards, K. Suszták, C. O’Donnell, A. Hung, T. Edwards, Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Million Veteran Program   +101 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats [PDF]

, 2016
BACKGROUND: Hypertension is a common problem in elderly cats. In most cats, systolic blood pressure (SBP) of
Bijsmans, E S, Doig, M, Elliott, J, Jepson, R E, Pelligand, L, Syme, H M   +5 more
core   +2 more sources

Intrinsic Blood Pressure [PDF]

Circulation, 1954
In this paper a concept of intrinsic blood pressure is formulated. This pressure was measured in 84 subjects with normal and abnormal vascular systems. It is concluded that shock, congestive failure, hypertension and the normal vascular system can be defined and understood in terms of intrinsic blood pressure.
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Aortic arterial stiffness associates with carotid intima-media thickness and carotid plaques in younger middle-aged healthy people

Blood Pressure
Purpose Aortic stiffness, assessed as estimated aortic pulse wave velocity (aPWV), and carotid intima-media thickness (cIMT) are markers of vascular age, and carotid plaques are a marker of early atherosclerosis. In this cross-sectional study we aimed to
Martina Söderström, Christer Grönlund, Per Liv, Emma Nyman, Ulf Näslund, Per Wester   +5 more
doaj   +1 more source

Blood pressure variability: clinical relevance and application

The Journal of Clinical Hypertension, 2018
Blood pressure variability is an entity that characterizes the continuous and dynamic fluctuations that occur in blood pressure levels throughout a lifetime.
G. Parati, G. Stergiou, E. Dolan, G. Bilo   +3 more
semanticscholar   +1 more source