Results 41 to 50 of about 496,642 (259)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Home Blood Pressure Measurement and Self-Interpretation of Blood Pressure Readings During Pregnancy: Hy-Result e-Health Prospective Study

Vascular Health and Risk Management, 2022
Nicolas Postel-Vinay,1,2 Jiali-Delphine Shao,3 Anne Pinton,4 Aude Servais,5 Nicole Gebara,1 Laurence Amar1 1Hypertension Unit, ESH Excellence Center, Hôpital Européen Georges Pompidou, APHP, Paris, France; 2Hospital at Home, Fondation Santé Service ...
Postel-Vinay N, Shao JD, Pinton A, Servais A, Gebara N, Amar L   +5 more
doaj  

Blood pressure measurement using only a smartphone

npj Digital Medicine, 2022
Hypertension is an immense challenge in public health. As one of the most prevalent medical conditions worldwide, it is a major cause of premature death.
Lorenz Frey, Carlo Menon, Mohamed Elgendi   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Office blood pressure measurement: A comprehensive review

The Journal of Clinical Hypertension, 2021
The conventional auscultatory methods for measuring blood pressure have been used to screen, diagnose, and manage hypertension since long. However, these have been found to be prone to errors especially the white coat phenomena which cause falsely high ...
Saulat Siddique, Aamir Hameed Khan, Hunaina Shahab, Yu‐Qing Zhang, Jam Chin Tay, Peera Buranakitjaroen, Yuda Turana, Narsingh Verma, Chen‐Huan Chen, Hao‐Min Cheng, Tzung‐Dau Wang, Huynh Van Minh, Yook‐Chin Chia, Kazuomi Kario   +13 more
doaj   +1 more source

Smartwatch-Based Blood Pressure Measurement Demonstrates Insufficient Accuracy

Frontiers in Cardiovascular Medicine, 2022
BackgroundNovel smartwatch-based cuffless blood pressure (BP) measuring devices are coming to market and receive FDA and CE labels. These devices are often insufficiently validated for clinical use.
Maarten Falter, Maarten Falter, Maarten Falter, Martijn Scherrenberg, Martijn Scherrenberg, Martijn Scherrenberg, Karen Driesen, Zoë Pieters, Toshiki Kaihara, Toshiki Kaihara, Toshiki Kaihara, Linqi Xu, Linqi Xu, Linqi Xu, Enrico Gianluca Caiani, Enrico Gianluca Caiani, Paolo Castiglioni, Andrea Faini, Gianfranco Parati, Gianfranco Parati, Paul Dendale, Paul Dendale   +21 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rural–urban difference in blood pressure measurement frequency among elderly with hypertension: a cross-sectional study in Shandong, China

Journal of Health, Population and Nutrition, 2018
Background Blood pressure measurement is the first step in preventing and controlling hypertension. The objective of this study is to examine the rural–urban difference towards blood pressure measurement among elderly with hypertension.
Qian Wang, Lingzhong Xu, Long Sun, Jiajia Li, Wenzhe Qin, Gan Ding, Jiao Zhang, Jing Zhu, Su Xie, Zihang Yu, Chengchao Zhou   +10 more
doaj   +1 more source