Results 111 to 120 of about 1,228,812 (242)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders

Frontiers in Cellular Neuroscience
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism of disease pathogenesis is not understood, certain biomarkers provide valuable insight
Duraisamy Kempuraj, Kirk D. Dourvetakis, Jessica Cohen, Daniel Seth Valladares, Rhitik Samir Joshi, Sai Puneeth Kothuru, Sai Puneeth Kothuru, Tristin Anderson, Baskaran Chinnappan, Amanpreet K. Cheema, Nancy G. Klimas, Nancy G. Klimas, Theoharis C. Theoharides, Theoharis C. Theoharides   +13 more
doaj   +1 more source

Effect of progesterone and utrogestan on functional liver condition in patients with dysfunctional uterine bleeding [PDF]

Саратовский научно-медицинский журнал, 2010
The effect of progesterone and utrogestan on protein synthetical, fermentative and chromogenic functions of liver in patients with dysfunctional uterine bleedings (DUB) has been studied.
Salekh R.Kh., Peshev L.P., Siprov A.V.
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis

Scientific Reports
Fibronectin type-III domain containing protein-5 (FNDC5), predominantly expressed in skeletal muscles, encodes FNDC5 transmembrane-protein. A segment of this protein is cleaved and secreted into blood as irisin, which promotes browning of white adipose ...
Sadaf Majeed, Hira Moin, Maaz Waseem, Zoya Khalid, Sumra Wajid Abbasi, Kashaf Rasool   +5 more
doaj   +1 more source

Mechanistic insights into the neuroprotective effects of Radix Astragali (Huang Qi): Bridging Traditional Chinese Medicine and modern pharmacology

Pharmacological Research - Modern Chinese Medicine
Introduction: Radix Astragali, a major herb in Traditional Chinese Medicine, has traditionally been used to strengthen vital energy and promote blood circulation.
Rizwan Ahmad, Chhavi Verma, Sandeep Kumar, Vishal Kumar, Darakhshan Gazala Bari, Saurabh Sharma, Shadab Ali, Shamim Shamim   +7 more
doaj   +1 more source

2008 Progress Report on Brain Research [PDF]

, 2008
Highlights new research on various disorders, nervous system injuries, neuroethics, neuroimmunology, pain, sense and body function, stem cells and neurogenesis, and thought and memory.
Eve Marder, Mahlon R. DeLong, Michael S. Gazzaniga, Thomas Wichmann   +3 more
core  

Direct reinfusion of pericardial blood complications: A case of acute respiratory distress syndrome and disseminated intravascular coagulation

Acute Medicine & Surgery
Background Direct reinfusion of pericardial blood during cardiac surgery triggers a systemic inflammatory response. Although various inflammatory mediators have been identified as triggers, the role of damage‐associated molecular patterns (DAMPs) remains
Takuto Yasuda, Kasumi Satoh, Nobuhisa Hirasawa, Manabu Okuyama, Hajime Nakae   +4 more
doaj   +1 more source

Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination

Scientific Reports
While Coronavirus disease 2019 (COVID-19) vaccines have proven to be both effective and generally safe, rare but severe adverse events following immunization (AEFIs) are described.
Ahmet Yalcinkaya, Marco Cavalli, Maribel Aranda-Guillén, Axel Cederholm, Almira Güner, Isabel Rietrae, Hedvig Mildner, Anish Behere, Oskar Eriksson, Laura Gonzalez, Constantin Habimana Mugabo, Anette Johnsson, Tadepally Lakshmikanth, Petter Brodin, Mia Wadelius, Pär Hallberg, Nils Landegren   +16 more
doaj   +1 more source