Results 251 to 260 of about 477,507 (338)

NIR-II Fluorescent Protein Created by In Situ Albumin-Tagging for Sensitive and Specific Imaging of Blood-Brain Barrier Disruption. [PDF]

Adv Sci (Weinh)
Xu J, Du Y, Zhu N, Li J, Zhang Y, Zhou D, Zhu S.   +6 more
europepmc   +1 more source

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source

High-throughput multiplexed gene and cell doping analysis through CRISPR-Cas12a system integrated with blood direct PCR. [PDF]

Sci Adv
Yi JY, Choi H, Kim M, Jeong Y, Hahn JS, Son B, Park HH, Sung C.   +7 more
europepmc   +1 more source

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

Using QIP-MS to Guide the Timing of MRD Testing in Patients With Multiple Myeloma: A Budget Impact Analysis From the French Payer Perspective. [PDF]

Clinicoecon Outcomes Res
Siegfried C, Amarapala M, Leleu X, Fusfeld L.   +3 more
europepmc   +1 more source

PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury

Advanced Science, EarlyView.
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan, Fang Yang, Linlin Hou, Yan Zhang, Xin Pang, Yuqi Du, Hongyi Yan, Huanzhou Zhu, Yue Cheng, Yue Wu, Pinpin Jiang, Mengnan Guo, Mengying Zhang, Jinjie Guo, Huihui Hao, Yong Jiang, Yi Li, Yanxia Gao   +17 more
wiley   +1 more source

A Rare Case of Takayasu Arteritis Presenting With Syncope and Elevated Inflammatory Markers in an Elderly Male With Learning Disability. [PDF]

Cureus
Ahamed F, Abdulmajeed M, Haider A, William J, Lee K.   +4 more
europepmc   +1 more source

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

Advanced Science, EarlyView.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou, Jia‐Xin Kou, Kai Zheng, Zi‐Xuan Guo, Hong‐Wei Fan, Wen‐Lian Li, Lu‐Lu Chu, Jing‐Wen Yin, Li‐Jie Liu, Zhi‐Gao Xiang, Feng Hu, Kai Shu, Ling‐Qiang Zhu, Dan Liu   +13 more
wiley   +1 more source

Raider of the lost <i>N-</i>glycans - Localizing rare and frequently overlooked IgG <i>N-</i>glycans with sulfation or bisecting LacNAc. [PDF]

Front Mol Biosci
Burock R, Chuzel L, Kähne T, Reichl U, Rapp E, Hennig R.   +5 more
europepmc   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source