Results 291 to 300 of about 1,056,334 (396)

Albumin-conjugation enables improved tumor targeting of aptamers via SPECT imaging. [PDF]

Mol Ther Nucleic Acids
Yang S, Zheng C, Cheng S, Wen L, Li P, Li J, Lan X, Jiang D.   +7 more
europepmc   +1 more source

In Situ and Real‐Time Multi‐Modality Imaging Guided Orderly Triple‐Therapy of Tumors with a Multifunctional Nanodrug

Advanced Science, EarlyView.
A multifunctional AuNR@SiO2@MnO2@ DNA prodrugs (ASMD) nanodrug is designed to establish an in situ and real‐time photoacoustic (PA)/magnetic resonance (MR)/fluorescence (FL) multi‐modality imaging guided orderly photothermal therapy (PTT)/chemodynamic therapy (CDT)/gene therapy (GT) triple‐therapy of tumor.
Chaoyi Yang, Yuexuan Meng, Ying An, Jing Jia, Yuru Wang, Guangming Li, Yiran Li, Shan Wu, Chengyao Geng, Yunlong Chen, Huangxian Ju   +10 more
wiley   +1 more source

Hemoglobin Disorders Associated with Neurological Impairment: First Report of ATR-X Syndrome and Recessive Congenital Methemoglobinemia Type II in Tunisia. [PDF]

Int J Mol Sci
Ouragini H, Bouatrous E, Kasdallah M, Nouira S, Dallali H, Rekaya S, Chaouachi D, Ouederni M, Menif S.   +8 more
europepmc   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

Associations Between Polymorphisms of the CSN1S1, CSN1S2, CSN2 and CSN3 Genes and Milk Composition Traits in Holstein Cattle. [PDF]

Vet Med Sci
Demirel AF, Çak B.
europepmc   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Restoration of pp60^Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells. [PDF]

Int J Mol Sci
Yegambaram M, Pokharel MD, Sun X, Lu Q, Soto J, Aggarwal S, Maltepe E, Fineman JR, Wang T, Black SM.   +9 more
europepmc   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits masquerading as renal-specific thrombotic microangiopathy. [PDF]

BMJ Case Rep
Duxbury HJ, Lee VW, Kwok F, Viswanathan S.   +3 more
europepmc   +1 more source