Results 301 to 310 of about 1,056,334 (396)

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Origin of poorly galactosylated IgA1 other than mucosa: a viewpoint from a report on patient with IgA vasculitis. [PDF]

Ren Fail
Huang M, Cao J, Li Y, Xu H, Wang M, Zheng Y, Shao M, Zeng Y, Lv J.   +8 more
europepmc   +1 more source

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

Hexavalent chromium induces ferroptosis in small intestinal tissue of broilers through GPX4/HMGB1/p38-MAPK pathway. [PDF]

Poult Sci
Wang J, Fan B, Liu W, Ma Z, Guo R, Guo J, Wang J, Zhang D, Sun Z, Liu C.   +9 more
europepmc   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Advanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo   +16 more
wiley   +1 more source

Screening of RNA methyltransferase NSP16 inhibitors against SARS-CoV-2 coronavirus and study of related mechanisms. [PDF]

Am J Transl Res
Fan X, Zhou D, Xu C, Song X, Wang X, Qin C, Zhu Z, Xu W, Zhu M.   +8 more
europepmc   +1 more source

Successful Management of Acquired von Willebrand Syndrome Associated with Monoclonal Gammopathy of Undetermined Significance After Sotorasib Treatment in a Patient with Non-Small-Cell Lung Carcinoma. [PDF]

Hematol Rep
Julien M, Pierre L, Gérout AC, Sattler L, Feugeas O, Desprez D.   +5 more
europepmc   +1 more source

The heterozygous mutation <i>COL4A4</i> c.817-1G>A causes Alport syndrome in a Chinese family: a case report. [PDF]

Front Pediatr
Wang D, Li X, Cheng K, Zheng L, Yu P, Lai P.   +5 more
europepmc   +1 more source

MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair. [PDF]

Noncoding RNA Res
Zhang J, Ma L, He L, Xu Q, Ding Y, Wang L.   +5 more
europepmc   +1 more source

Proteomic Identification and Functional Analysis of Babesia microti Reveals Heparin-Binding Proteins. [PDF]

J Trop Med
Cai YC, Xu B, Chu YH, Yu YF, Sun JH, Mo ZR, Yang HY, Yan SN, Chen MX, Chen JX.   +9 more
europepmc   +1 more source