Results 101 to 110 of about 2,909,536 (305)

Isolation of Genomic DNA from Blood Using a Novel Filter-Based DNA Purification Technology

open access: yes, 2001
A novel DNA purification technology is described that enables the purification of pure dsDNA from blood. When compared to existing DNA purification methods, the Whatman BioScience Purification System (WBPS) offers a fast and convenient way to recover ...
C. Bridge   +7 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Hypothetical simulation of blood purification treatment.

open access: yes, 2013
Ten thousands parameter samples from the non-survivor population were simulated with or without the extracorporeal blood purification device. Black denotes the sham case (without treatment), blue denotes the survivor case after the treatment, and red ...
John A. Kellum (330062)   +5 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Purification of the human blood platelet thromboxane A(2)/prostaglandin H(2) receptor protein.

open access: yes, 1991
Purification of the human blood platelet thromboxane A(2)/prostaglandin H(2) receptor ...
Sun-Ok. Kim (7949978)
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Cardiovascular function and arterial blood gases during isolated ultrafiltration in healthy man

open access: yes, 1988
In order to recognize possible cardiovascular signs of underhydration during isolated ultrafiltration (IUF), we have studied the physiological hemodynamic adaptation to IUF in healthy man both above and below normohydration.
Bergström, J   +2 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Construction and validation of a risk predictive model for protein-energy wasting in hemodialysis patients

open access: yesLinchuang shenzangbing zazhi
Objective To explore the incidence and risk factors of protein-energy wasting (PEW) in patients on maintenance hemodialysis (MHD) and construct a visual risk predictive model and verify its predictive performance.
Ming-mei Ding   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

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