Results 191 to 200 of about 181,790 (260)

Enhancing Emergency Trauma Management Skills Through Simulation: A Quality Improvement Initiative in Ghana. [PDF]

Cureus
Dike NO, Okyere P, Kajjimu J, Achampong EK.   +3 more
europepmc   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Design, Manufacturing, and Educational Evaluation of a Low-Cost Venipuncture Training Simulator. [PDF]

Cureus
Tserovski S, Papadakis K, Yanev KK, Mileva-Popova RD, Bogdanov TG.   +4 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications. [PDF]

Eng Comput
Luo C, Li K, Herschman AR, Sun M, Waisman H, Vedula V, Kysar JW, Kalfa D.   +7 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

One-dimensional computational circulatory models: a scoping review. [PDF]

Einstein (Sao Paulo)
Nóbrega GACL, Garzon S, Blanco PJ, Lemos Neto PA.   +3 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Editorial Note: Ultra-compact quintuple-band terahertz metamaterial biosensor for enhanced blood cancer diagnostics. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Effectiveness of low-fidelity versus high-fidelity interprofessional simulation on the acquisition of theoretical and practical knowledge of arterial blood gas testing: a parallel randomized controlled trial (ELVHIS-ABG-RCT) protocol. [PDF]

BMC Nurs
Conti A, Bidoggia F, Daga FA, Ferraris A, Penso R, Piovan C, Simionato L, Lembo D, Sciascia S, Advanced MedSim Team.   +9 more
europepmc   +1 more source